Could less heart screening be safer for kidney transplant patients?

NCT ID NCT03674307

Ongoing Knowledge-focused Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial investigates whether kidney transplant candidates on dialysis can safely skip routine heart screening after being placed on the waiting list. Participants are randomly assigned to either no further screening or regular annual screening for hidden coronary artery disease. The study compares rates of major cardiac events like heart attacks and cardiac death between the two groups. If no screening proves non-inferior, it could change standard care and reduce unnecessary procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If skipping routine heart screening proves safe, it could simplify care for kidney transplant candidates and reduce unnecessary tests.
What could go wrong: This is a large trial, but it only tests a screening strategy, not a treatment. The results may not apply to all patients, and there is a risk that less screening could miss hidden heart problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder chronic kidney disease dialysis disequilibrium syndrome end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES DIALYSIS RELATED COMPLICATION END-STAGE RENAL DISEASE KIDNEY TRANSPLANTATION

Contacts and locations

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Locations

Barts Health NHS Trust

London, E1 4UJ, United Kingdom
CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec

Laval, Quebec, Canada
Charité Universitätsmedizin

Berlin, Germany
Dalhousie University

Halifax, Nova Scotia, B3H 1V8, Canada
Epsom and St Helier University Hospitals NHS Trust

Carshalton, SM5 1AA, United Kingdom
King's College Hospital NHS Foundation Trust

Brixton, SW9 8RR, United Kingdom
Kingston Health Science Centre

Kingston, Ontario, Canada
London Health Science Centre

London, Ontario, Canada
McGill University Health Centre

Montreal, Quebec, Canada
St George's University Hospital NHS Trust Foundation

London, United Kingdom
St Michael's Hospital

Toronto, Ontario, Canada
St. Joseph's Healthcare

Hamilton, Ontario, L8N 4A6, Canada
St. Paul's Hospital, University of Saskatchewan

Saskatoon, Saskatchewan, Canada
Sussex Brighton R&D

Brighton, BN2 1ES, United Kingdom
The George Washington University

Washington D.C., District of Columbia, 20052, United States
The Ottawa Hospital Research Institute

Ottawa, Ontario, K1H 7W9, Canada
Universite de Montreal, Hopital Maisonneuve-Rosemont

Montreal, Quebec, Canada
University Health Network

Toronto, Ontario, M5G 2N2, Canada
University of Alberta

Edmonton, Alberta, Canada
University of Arizona

Tucson, Arizona, 85724, United States
University of British Columbia

Vancouver, British Columbia, V6Z 1Y6, Canada
University of Montreal, Maisonneuve-Rosemont Hospital

Montreal, Quebec, H1T 2M4, Canada

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