Could a diabetes drug help heart failure patients shed excess fluid?

NCT ID NCT05553938

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication, and measure how much salt and water their kidneys remove. The goal is to see if empagliflozin improves fluid balance, which could ease symptoms like swelling and shortness of breath.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

empagliflozin

What this could lead to

If successful, this could show that empagliflozin helps heart failure patients get rid of excess fluid more effectively, potentially reducing hospital visits.

What could go wrong

This is an early-phase study with only 60 participants, so results may not apply to all heart failure patients. The drug may not improve fluid removal or could cause side effects like dehydration or kidney issues.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

More trials for these conditions

Other studies related to the condition(s) this trial covers.

Contacts and locations

Locations

  • Yale New Haven Hospital

    New Haven, Connecticut, 06520, United States

  • Yale University

    New Haven, Connecticut, 06520, United States