Major trial pits drugs vs. surgery vs. stents for failing hearts
NCT ID NCT06566183
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, heart events, cognitive function, and quality of life to determine the most effective treatment strategy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Guideline-directed medical therapy, coronary artery bypass grafting, and percutaneous coronary intervention
What this could lead to
If successful, this trial could show which treatment—medication, bypass surgery, or stenting—is best for improving survival, heart function, and thinking skills in people with advanced heart disease.
What could go wrong
This trial is currently suspended, and results may not apply to all patients. The study is large but still uncertain, and all procedures carry risks like infection, bleeding, or heart complications.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEART FAILURE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
International Study Site
International Study Site, Brazil
-
International Study Site
International Study Site, India
-
International Study Site
International Study Site, Mexico
-
International Study Site
International Study Site, Poland
-
International Study Site
International Study Site, South Korea
-
NYU Langone Health
New York, New York, 10016, United States