Major trial pits drugs vs. surgery vs. stents for failing hearts

NCT ID NCT06566183

Terminated Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, heart events, cognitive function, and quality of life to determine the most effective treatment strategy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Guideline-directed medical therapy, coronary artery bypass grafting, and percutaneous coronary intervention
What this could lead to: If successful, this trial could show which treatment—medication, bypass surgery, or stenting—is best for improving survival, heart function, and thinking skills in people with advanced heart disease.
What could go wrong: This trial is currently suspended, and results may not apply to all patients. The study is large but still uncertain, and all procedures carry risks like infection, bleeding, or heart complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction coronary artery disorder heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE IMPAIRMENT CORONARY ARTERY DISEASE HEART FAILURE

Contacts and locations

Locations

International Study Site

International Study Site, Brazil
International Study Site

International Study Site, India
International Study Site

International Study Site, Mexico
International Study Site

International Study Site, Poland
International Study Site

International Study Site, South Korea
NYU Langone Health

New York, New York, 10016, United States

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