Radioactive water scan could spot hidden heart disease

NCT ID NCT05134012

Ongoing Diagnosis Sponsor: MedTrace Pharma A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This phase 3 trial is testing whether a special PET scan using radioactive water ([15-O]-H2O) can accurately detect coronary artery disease. About 215 adults with suspected heart disease will receive the injection at rest and during stress, then compare results to standard tests. The goal is to confirm if this imaging method is a reliable, non-invasive diagnostic tool.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [15-O]-H2O (radioactive water) injection
What this could lead to: If successful, this could provide a more accurate, non-invasive way to diagnose coronary artery disease, potentially reducing the need for invasive procedures.
What could go wrong: This is a diagnostic trial, not a treatment. The test may not prove accurate enough in all patient groups, and results may not change patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

Aarhus University Hospital

Aarhus, Denmark
Amsterdam University Medical Center, Department of Radiology and Nuclear Medicine

Amsterdam, North Holland, 1081HV, Netherlands
Department of Cardiology and Angiology -- Hannover Medical School (MHH)

Hanover, Germany
Mayo Clinic

Rochester, Minnesota, 55905, United States
Norrland University Hospital Heart Center

Umeå, Sweden
Sahlgrenska University Hospital

Gothenburg, Sweden
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
University Hospital Freiburg, Clinic for Nuclear Medicine

Freiburg im Breisgau, Germany
University of Iowa

Iowa City, Iowa, 52242, United States
University of Ottawa Heart Institute

Ottawa, Ontario, Canada
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Virginia Medical Center

Charlottesville, Virginia, 22903, United States
Washington University

St Louis, Missouri, 63110, United States

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