Massive gene sequencing project aims to unlock secrets of heart disease

NCT ID NCT00410241

Ongoing Knowledge-focused Sponsor: National Human Genome Research Institute (NHGRI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how results affect health behaviors and family communication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could improve how we interpret genetic information and link gene changes to health conditions like heart disease.
What could go wrong: This is an observational pilot study, not a treatment trial. It may not directly benefit participants, and the genetic findings may be uncertain or hard to interpret.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis coronary artery disorder coronary atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROTIC HEART DISEASE HEALTHY VOLUNTEERS

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
Suburban Hospital

Bethesda, Maryland, 20814, United States

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