Experimental antibody drug aims to tackle stubborn high blood pressure
NCT ID NCT06833190
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an experimental drug called REGN5381 in 34 adults with uncontrolled hypertension (high blood pressure despite taking one or more blood pressure medications). The drug is a monoclonal antibody designed to activate NPR1 receptors, which may help lower blood pressure. The trial was a Phase 2b, randomized, double-blind, placebo-controlled study, but it was terminated early, so the full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
REGN5381 (a monoclonal antibody that targets NPR1 receptors to help lower blood pressure)
What this could lead to
If it works, this could offer a new treatment option for people whose high blood pressure is not controlled by current medications.
What could go wrong
This was a small, early-phase trial that was terminated, so results are limited. The drug may not prove effective or safe in larger studies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Protas, Car Park of Asda Huyton Supercentre
Huyton, Liverpool, L36 7TX, United Kingdom
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Protas, Car Park of Asda Pilsworth Road
Bury, BL9 8RS, United Kingdom
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Protas, Two New Bailey Square
Salford, Manchester, M3 5GS, United Kingdom