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New biologic KER-012 shows promise for Hard-to-Treat lung condition

NCT ID NCT05975905

Terminated Disease control Sponsor: Keros Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This phase 2 trial tested an experimental biologic called KER-012 in 113 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. Participants received either KER-012 or a placebo as a shot every 4 weeks, on top of their usual PAH medications. The study measured changes in lung blood pressure and exercise ability to see if the drug could improve symptoms and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
KER-012 (a biologic drug given as a shot under the skin every 4 weeks)
What this could lead to
If it works, KER-012 could become a new add-on treatment to help people with pulmonary arterial hypertension breathe easier and be more active.
What could go wrong
This is a mid-stage trial with only 113 participants, so results may not apply to everyone. The drug is still experimental, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY ARTERIAL HYPERTENSION

Contacts and locations

Locations

  • Site PI TROPOS Study Site 104

    Stanford, California, 94305, United States

  • TROPOS Study Site 100

    Kansas City, Kansas, 66160, United States

  • TROPOS Study Site 101

    Ann Arbor, Michigan, 481091, United States

  • TROPOS Study Site 102

    Houston, Texas, 77030, United States

  • TROPOS Study Site 103

    Boston, Massachusetts, 02111, United States

  • TROPOS Study Site 105

    Torrance, California, 90502, United States

  • TROPOS Study Site 106

    Charleston, South Carolina, 29425, United States

  • TROPOS Study Site 107

    Tucson, Arizona, 85719, United States

  • TROPOS Study Site 108

    Jacksonville, Florida, 32224, United States

  • TROPOS Study Site 109

    Boston, Massachusetts, 02115, United States

  • TROPOS Study Site 110

    Louisville, Kentucky, 40202, United States

  • TROPOS Study Site 111

    Scottsdale, Arizona, 85258, United States

  • TROPOS Study Site 112

    Dallas, Texas, 75390, United States

  • TROPOS Study Site 113

    Cincinnati, Ohio, 45221, United States

  • TROPOS Study Site 114

    Albuquerque, New Mexico, 87106, United States

  • TROPOS Study Site 115

    St Louis, Missouri, 63110, United States

  • TROPOS Study Site 200

    Blumenau, 89030, Brazil

  • TROPOS Study Site 201

    São Paulo, 05403, Brazil

  • TROPOS Study Site 202

    Porto Alegre, 90020, Brazil

  • TROPOS Study Site 320

    Le Kremlin-Bicêtre, 94270, France

  • TROPOS Study Site 340

    Hanover, 30625, Germany

  • TROPOS Study Site 341

    Giesen, 35392, Germany

  • TROPOS Study Site 342

    Leipzig, 04103, Germany

  • TROPOS Study Site 343

    Heidelberg, 69120, Germany

  • TROPOS Study Site 344

    Homburg, 66424, Germany

  • TROPOS Study Site 345

    Regensburg, 93053, Germany

  • TROPOS Study Site 400

    Lisbon, 1769-001, Portugal

  • TROPOS Study Site 401

    Porto, 4099-001, Portugal

  • TROPOS Study Site 402

    Coimbra, 3000-075, Portugal

  • TROPOS Study Site 403

    Almada, 2805-267, Portugal

  • TROPOS Study Site 410

    Madrid, 28041, Spain

  • TROPOS Study Site 411

    Santander, 39008, Spain

  • TROPOS Study Site 412

    Barcelona, 39008, Spain

  • TROPOS Study Site 413

    Barcelona, 8035, Spain

  • TROPOS Study Site 440

    London, W12 0HS, United Kingdom

  • TROPOS Study Site 441

    Glasgow, G81 4DY, United Kingdom

  • TROPOS Study Site 442

    London, SW3 6NP, United Kingdom

  • TROPOS Study Site 701

    Krakow, 31-202, Poland

  • TROPOS Study Site 702

    Otwock, 05-400, Poland

  • TROPOS Study Site 703

    Poznan, 60-355, Poland

  • TROPOS Study Site 704

    Gdansk, 80-214, Poland

  • TROPOS Study Site 705

    Lodz, 91-347, Poland

  • TROPOS Study Site 706

    Poznan, 61-848, Poland

  • TROPOS Study Site 800

    Darlinghurst, 2010, Australia

  • TROPOS Study Site 801

    Sydney, 2095, Australia

  • TROPOS Study Site 803

    New Lambton Heights, 2305, Australia

  • TROPOS Study Site 804

    Camperdown, 2050, Australia

  • TROPOS Study Site 805

    Melbourne, Victoria, 3004, Australia

  • TROPOS Study Site 807

    Auchenflower, 4066, Australia

  • TROPOS Study Site 880

    Seoul, 06351, South Korea

  • TROPOS Study Site 881

    Incheon, 21565, South Korea

  • TROPOS Study Site 882

    Seoul, 03722, South Korea

  • TROPOS Study Site 883

    Seoul, 03080, South Korea

  • TROPOS Study Site 890

    Taipei, 11217, Taiwan

  • TROPOS Study Site 891

    Kaohsiung City, 81362, Taiwan

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