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New PAH drug shows promise in Mid-Stage trial

NCT ID NCT05975905

Completed Disease control Sponsor: Keros Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 24 times

Summary

This study tested an investigational drug called KER-012 in 113 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. Participants took KER-012 or a placebo alongside their usual PAH medications. The goal was to see if KER-012 improves blood flow in the lungs and exercise ability, while checking for side effects.

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Contacts and locations

Locations

  • Site PI TROPOS Study Site 104

    Stanford, California, 94305, United States

  • TROPOS Study Site 100

    Kansas City, Kansas, 66160, United States

  • TROPOS Study Site 101

    Ann Arbor, Michigan, 481091, United States

  • TROPOS Study Site 102

    Houston, Texas, 77030, United States

  • TROPOS Study Site 103

    Boston, Massachusetts, 02111, United States

  • TROPOS Study Site 105

    Torrance, California, 90502, United States

  • TROPOS Study Site 106

    Charleston, South Carolina, 29425, United States

  • TROPOS Study Site 107

    Tucson, Arizona, 85719, United States

  • TROPOS Study Site 108

    Jacksonville, Florida, 32224, United States

  • TROPOS Study Site 109

    Boston, Massachusetts, 02115, United States

  • TROPOS Study Site 110

    Louisville, Kentucky, 40202, United States

  • TROPOS Study Site 111

    Scottsdale, Arizona, 85258, United States

  • TROPOS Study Site 112

    Dallas, Texas, 75390, United States

  • TROPOS Study Site 113

    Cincinnati, Ohio, 45221, United States

  • TROPOS Study Site 114

    Albuquerque, New Mexico, 87106, United States

  • TROPOS Study Site 115

    St Louis, Missouri, 63110, United States

  • TROPOS Study Site 200

    Blumenau, 89030, Brazil

  • TROPOS Study Site 201

    São Paulo, 05403, Brazil

  • TROPOS Study Site 202

    Porto Alegre, 90020, Brazil

  • TROPOS Study Site 320

    Le Kremlin-Bicêtre, 94270, France

  • TROPOS Study Site 340

    Hanover, 30625, Germany

  • TROPOS Study Site 341

    Giesen, 35392, Germany

  • TROPOS Study Site 342

    Leipzig, 04103, Germany

  • TROPOS Study Site 343

    Heidelberg, 69120, Germany

  • TROPOS Study Site 344

    Homburg, 66424, Germany

  • TROPOS Study Site 345

    Regensburg, 93053, Germany

  • TROPOS Study Site 400

    Lisbon, 1769-001, Portugal

  • TROPOS Study Site 401

    Porto, 4099-001, Portugal

  • TROPOS Study Site 402

    Coimbra, 3000-075, Portugal

  • TROPOS Study Site 403

    Almada, 2805-267, Portugal

  • TROPOS Study Site 410

    Madrid, 28041, Spain

  • TROPOS Study Site 411

    Santander, 39008, Spain

  • TROPOS Study Site 412

    Barcelona, 39008, Spain

  • TROPOS Study Site 413

    Barcelona, 8035, Spain

  • TROPOS Study Site 440

    London, W12 0HS, United Kingdom

  • TROPOS Study Site 441

    Glasgow, G81 4DY, United Kingdom

  • TROPOS Study Site 442

    London, SW3 6NP, United Kingdom

  • TROPOS Study Site 701

    Krakow, 31-202, Poland

  • TROPOS Study Site 702

    Otwock, 05-400, Poland

  • TROPOS Study Site 703

    Poznan, 60-355, Poland

  • TROPOS Study Site 704

    Gdansk, 80-214, Poland

  • TROPOS Study Site 705

    Lodz, 91-347, Poland

  • TROPOS Study Site 706

    Poznan, 61-848, Poland

  • TROPOS Study Site 800

    Darlinghurst, 2010, Australia

  • TROPOS Study Site 801

    Sydney, 2095, Australia

  • TROPOS Study Site 803

    New Lambton Heights, 2305, Australia

  • TROPOS Study Site 804

    Camperdown, 2050, Australia

  • TROPOS Study Site 805

    Melbourne, Victoria, 3004, Australia

  • TROPOS Study Site 807

    Auchenflower, 4066, Australia

  • TROPOS Study Site 880

    Seoul, 06351, South Korea

  • TROPOS Study Site 881

    Incheon, 21565, South Korea

  • TROPOS Study Site 882

    Seoul, 03722, South Korea

  • TROPOS Study Site 883

    Seoul, 03080, South Korea

  • TROPOS Study Site 890

    Taipei, 11217, Taiwan

  • TROPOS Study Site 891

    Kaohsiung City, 81362, Taiwan

Conditions

Explore the condition pages connected to this study.

PULMONARY ARTERIAL HYPERTENSION