Botulinum toxin injection aimed at easing leg spasticity after stroke or injury

NCT ID NCT04099667

Terminated Symptom relief Sponsor: Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether MYOBLOC, a botulinum toxin injection, can safely reduce muscle stiffness in the lower leg of adults with spasticity caused by stroke, brain injury, or spinal cord injury. About 40 participants received either a low or high dose of MYOBLOC or a placebo injection. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MYOBLOC (rimabotulinumtoxinB, botulinum toxin type B)
What this could lead to: If it works, this could provide a treatment option to reduce leg muscle stiffness and improve movement in adults with spasticity.
What could go wrong: The study was terminated early with only 40 participants, so results are limited. Botulinum toxin injections can cause muscle weakness or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic hemiplegia Muscle Spasticity stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPASTICITY

Contacts and locations

Locations

Centrum Medyczne Linden

Krakow, 31-721, Poland
Coastal Neurology

Port Royal, South Carolina, 29935, United States
Idaho Physical Medicine and Rehabilitation

Boise, Idaho, 83706, United States
National Institute of Medical Rehabilitation

Budapest, H-1121, Hungary
Niepubliczny Zaklad Opieki Zdrowotnej (NZOZ) Neuromed

Lubin, 20-604, Poland
Rancho Research Institute

Downey, California, 90242, United States
Specjalistyczna Praktyka Lekarska

Katowice, 40-097, Poland
Specjalistyczne Gabinety

Krakow, 30-539, Poland
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

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