Numbing shot may cut opioid need after leg surgery, but trial stalls
NCT ID NCT05992896
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization, but it was terminated early after only 3 participants. Because of the small size, no meaningful conclusions can be drawn about the drug's effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal bupivacaine (a long-acting numbing medicine)
What this could lead to
If it worked, this approach could help patients use fewer narcotics after leg surgery, potentially reducing side effects and addiction risk.
What could go wrong
The trial was terminated early with only 3 participants, so no reliable conclusions can be drawn. The results may not apply to a broader population.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Health System - Eau Claire
Eau Claire, Wisconsin, 54703, United States