Numbing shot may cut opioid need after leg surgery, but trial stalls

NCT ID NCT05992896

Terminated Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization, but it was terminated early after only 3 participants. Because of the small size, no meaningful conclusions can be drawn about the drug's effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liposomal bupivacaine (a long-acting numbing medicine)
What this could lead to: If it worked, this approach could help patients use fewer narcotics after leg surgery, potentially reducing side effects and addiction risk.
What could go wrong: The trial was terminated early with only 3 participants, so no reliable conclusions can be drawn. The results may not apply to a broader population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Narcotic-Related Disorders peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL ARTERIAL DISEASE

Contacts and locations

Locations

Mayo Clinic Health System - Eau Claire

Eau Claire, Wisconsin, 54703, United States

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