Abandoned study: can a common painkiller help close a tiny heart vessel in preemies?

NCT ID NCT03701074

Terminated Disease control Sponsor: University of South Alabama Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether adding acetaminophen to standard ibuprofen treatment could better close a blood vessel (ductus arteriosus) that stays open too long in very premature infants. The trial was planned for preterm babies born at or before 27 weeks and 6 days who needed breathing support. However, the study was stopped early after enrolling only one participant, so no meaningful conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetaminophen and ibuprofen
What this could lead to: If it worked, this could point toward a more effective way to close a common heart vessel issue in premature babies, potentially reducing complications.
What could go wrong: The trial was terminated very early with only one participant, so we have almost no data. It is unclear if the combination is safe or effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bronchopulmonary dysplasia patent ductus arteriosus Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHOPULMONARY DYSPLASIA PATENT DUCTUS ARTERIOSUS PRETERM INFANT

Contacts and locations

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Locations

University of South Alabama

Mobile, Alabama, 36607, United States

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