Clotting drug may replace plasma transfusions in heart surgery
NCT ID NCT04244981
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compared two treatments to reduce bleeding after heart valve surgery: a concentrated clotting drug (PCC) versus fresh frozen plasma (FFP). The trial planned to enroll 476 adults undergoing elective valve surgery. It was terminated early, so the full comparison was not completed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prothrombin Complex Concentrate (PCC)
What this could lead to
If it works, this could offer a faster, more standardized way to control bleeding after heart valve surgery, potentially reducing the need for plasma transfusions.
What could go wrong
This trial was terminated early, so results are limited. It is a non-inferiority study, meaning it only aims to show PCC is not worse than plasma, not that it is better. Bleeding risks and side effects like clotting are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC
Beijing, Beijing Municipality, 100037, China
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China