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Cancer clot study halted: new drug vs standard care

NCT ID NCT05171049

Disease control Sponsor: Anthos Therapeutics, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new blood thinner, abelacimab, against the standard drug apixaban in about 1,150 people with cancer who had a blood clot. The goal was to see which drug better prevented new clots and caused less bleeding. The study was stopped early, but the results may still help doctors choose safer treatments for cancer patients at risk of dangerous clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,150 people

The number who actually took part.

Started

May 2022

Finished

Feb 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female subjects ≥18 years old or other legal maturity age according to the country of residence * Confirmed diagnosis of cancer (by histology, adequate imaging modality), other than basal-cell or squamous-cell carcinoma of the skin alone with one of the following: * Active cancer, defined as either locally active, regionally invasive, or metastatic cancer at the time of randomization and/or * Currently receiving or having received anticancer therapy (radiotherapy, chemotherapy, hormonal therapy, any kind of targeted therapy or any other anticancer therapy) in the last 6 months. * Confirmed symptomatic or incidental proximal lower limb deep vein thrombosis (DVT) (i.e., popliteal, femoral, iliac, and/or inferior vena cava \[IVC\] thrombosis) and/or a confirmed symptomatic pulmonary embolism (PE), or an incidental PE in a segmental, or larger pulmonary artery. Patients are eligible within 120 hours from diagnosis of the qualifying VTE * Anticoagulation therapy with a therapeutic dose of DOAC for at least 6 months is indicated * Able to provide written informed consent Exclusion Criteria: * Thrombectomy, insertion of a caval filter or use of a fibrinolytic agent to treat the current (index) DVT and/or PE * More than 120 hours of pre-treatment with therapeutic doses of UFH, LMWH, fondaparinux, DOAC, or other anticoagulants * An indication to continue treatment with therapeutic doses of an anticoagulant other than that VTE treatment prior to randomization (e.g., atrial fibrillation \[AF\], mechanical heart valve, prior VTE) * Platelet count \<50,000/mm3 at the screening visit * PE leading to hemodynamic instability (blood pressure \[BP\] \<90 mmHg or shock) * Acute ischemic or hemorrhagic stroke or intracranial hemorrhage within the 4 weeks preceding screening * Brain trauma or a cerebral or spinal cord surgery or spinal procedures such as lumbar puncture or epidural/spinal anesthesia within 4 weeks of screening * Need for aspirin in a dosage of \>100 mg/day or any other antiplatelet agent alone or in combination with aspirin * Primary brain cancer or untreated intracranial metastases at baseline * Acute myeloid or lymphoid leukemia * Bleeding requiring medical attention at the time of randomization or in the preceding 4 weeks * Planned brain, spinal cord, cardiac, vascular, major thoracic and/or major abdominal surgery in the 4 weeks following randomization * Eastern Cooperative Oncology Group (ECOG) performance status of 3 or 4 at screening * Life expectancy \<3 months at randomization * Calculated creatinine clearance (CrCl) \<30 mL/min (Cockcroft-Gault equation) at the screening visit * Hemoglobin \<8 g/dL at the screening visit * Acute hepatitis, chronic active hepatitis, liver cirrhosis; or an alanine aminotransferase (ALT) ≥3 x and/or bilirubin ≥2 x upper limit of normal (ULN) at the screening visit in absence of clinical explanation * Uncontrolled hypertension (systolic BP\>180 mm Hg or diastolic BP \>100 mm Hg despite antihypertensive treatment) * Women of child-bearing potential (WOCBP) who are unwilling or unable to use highly effective contraceptive measures during the study from screening up to 3 days after last treatment of apixaban or 100 days after administration of abelacimab (See Section 5.3.6. for highly effective contraceptive measures) * Sexually active males with sexual partners of childbearing potential must agree to use a condom or other reliable contraceptive measure up to 3 days after last treatment of apixaban or 100 days after administration of abelacimab * Pregnant or breast-feeding women * Patients known to be receiving strong dual inducers or inhibitors of both CYP3A4 and P gp * History of hypersensitivity to any of the study drugs (including apixaban) or excipients, to drugs of similar chemical classes, or any contraindication listed in the label for apixaban * Subjects with any condition that in the Investigator's judgement would place the subject at increased risk of harm if he/she participated in the study * Use of other investigational (not registered) drugs within 5 half-lives prior to enrollment or until the expected pharmacodynamic(s) (PD) effect has returned to baseline, whichever is longer. Participation in academic non-interventional studies or interventional studies, comprising testing different strategies or different combinations of registered drugs is permitted

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Conditions

The condition(s) this trial relates to.

pulmonary embolism venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep venous thrombosis Pulmonary embolism Venous thromboembolism

Contacts and locations

Locations

  • 1st Affiliate Hospital of Xi'an Jiao

    Xi'an, 710061, China

  • A.O.U. Policlinico di Modena

    Modena, 41124, Italy

  • Akershus Univeristy Hospital

    Lørenskog, 1478, Norway

  • Albert Schweitzer Ziekenhuis, Dordwijk

    Dordrecht, 3317, Netherlands

  • Amsterdam University Medical Center

    Holland, 1105AZ, Netherlands

  • Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia

    Bologna, 40133, Italy

  • Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia

    Reggio Emilia, 42123, Italy

  • Azienda Ospedale - Università Padova

    Padova, 35128, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Azienda Ospedaliero Universitaria San Martino

    Genova, 16132, Italy

  • Azienda Ospedaliero Universitaria di Parma

    Parma, 43100, Italy

  • Azienda Ospedaliero-Universitaria Santa Maria della Misericordia

    Udine, 33100, Italy

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, 24127, Italy

  • Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo

    Milan, 20142, Italy

  • Bacs-Kiskun County Hospital

    Kecskemét, 6000, Hungary

  • Barts Health NHS Trust

    London, ENG, E1 188, United Kingdom

  • Beaumont Hospital

    Dublin, V2N0, Ireland

  • Beijing Shijitan Hosp.

    Beijing, 100038, China

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215-5400, United States

  • Blacktown Hospital

    Blacktown, New South Wales, 2148, Australia

  • Blood Center of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Bon Secour Hospital

    Cork, Ireland

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CH Le Puy en Velay

    Le Puy-en-Velay, 43000, France

  • CHU Amiens - Hopital Nord

    Amiens, 80057, France

  • CHU Angers - Hôpital Hôtel Dieu

    Angers, 49933, France

  • CHU Clermont Ferrand - Hopital Gabriel Montpied

    Clermont-Ferrand, 63003, France

  • CHU Dijon - Hôpital Bocage Central

    Dijon, 21079, France

  • CHU Strasbourg - Nouvel Hôpital Civil

    Strasbourg, 67091, France

  • CHU de Brest - Hôpital de la Cavale Blanche

    Brest, 29609, France

  • CHU de Grenoble - Hôpital Albert Michallon

    Grenoble, 38043, France

  • CHU de Limoges - Hôpital Dupuytren

    Limoges, 87042, France

  • CHU de Nancy - Hôpital de Brabois Adultes

    Vandœuvre-lès-Nancy, 54500, France

  • CHU de Nancy - Hôpital de Brabois Adultes

    Vandœuvre-lès-Nancy, 54511, France

  • CHU de Rouen - Hôpital de Bois Guillaume

    Rouen, 76031, France

  • CHU de Saint-Etienne - Hopital Nord

    Saint-Etienne, 42000, France

  • CHU de Toulouse - Hôpital Rangueil

    Toulouse, 31059, France

  • Castle Hill Hospital, Department of Oncology & Haematology

    Cottingham, ENG, HU16 5JQ, United Kingdom

  • Centre Hospitalier Intercommunal de Toulon

    Toulon, 83000, France

  • Centre Hospitalier Universitaire Vaudois

    Lausanne, 1011, Switzerland

  • Centre hospitalier des pays de Morlaix

    Morlaix, 29600, France

  • Chibaken Saiseikai Narashino Hospital

    Chiba, 275-0006, Japan

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Clinica Universidad de Navarra

    Madrid, 28027, Spain

  • Clinica Universidad de Navarra

    Pamplona, 31008, Spain

  • Complejo Hospitalario Universitario de Orense

    Ourense, 32005, Spain

  • Complejo Hospitalario Universitario de Santiago

    Santiago de Compostela, 15706, Spain

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139, Australia

  • Cork University Hospital

    Cork, Ireland

  • Corporacio Sanitaria Parc Tauli

    Sabadell, 8208, Spain

  • Daegu Catholic University Medical Center

    Daegu, 42472, South Korea

  • Daugavpils Regional Hospital

    Daugavpils, LV-5417, Latvia

  • Debreceni Egyetem

    Debrecen, H-4032, Hungary

  • Dong-A University Hospital

    Seogu, 49201, South Korea

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Ewha Womans University Mokdong Hospital

    Yangcheon, 07985, South Korea

  • Far Eastern Memorial Hospital

    New Taipei City, 220, Taiwan

  • Fondazione Policlinico Universitario A. Gemelli IRCCS.

    Roma, 168, Italy

  • Groupe Hospitalier Pitie-Salpetriere

    Paris, 75651, France

  • Gundersen Health System

    La Crosse, Wisconsin, 54601, United States

  • Haga Ziekenhuis

    The Hague, 2545 AA, Netherlands

  • Hallym University Sacred Heart Hospital

    Anyang, 14068, South Korea

  • Hamilton Health Sciences, Juravinski Hospital and Cancer Centre

    Hamilton, Ontario, L8V 1C3, Canada

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Hopital Timone Adultes

    Marseille, 13385, France

  • Hopital Universitaire Geneve

    Geneva, 1205, Switzerland

  • Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud

    Pierre-Bénite, 69310, France

  • Hospital Clinic de Barcelona

    Barcelona, 8036, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital General Universitario de Elche

    Elche, 3203, Spain

  • Hospital Universitario Ciudad de Jaen

    Jaén, 23007, Spain

  • Hospital Universitario Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Universitario Del Vinalopo

    Elche, 03001, Spain

  • Hospital Universitario Infanta Leonor

    Madrid, 28031, Spain

  • Hospital Universitario Lucus Augusti

    Lugo, 27003, Spain

  • Hospital Universitario Marques de Valdecilla

    Santander, 39012, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, 28220, Spain

  • Hospital Universitario Virgen de las Nieves

    Granada, 18014, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hospital de la Santa Creu I Sant Pau

    Barcelona, 8041, Spain

  • Huizhou Municipal Central Hospital

    Huizhou, 516001, China

  • Hôpital Européen Georges Pompidou

    Paris, 75015, France

  • Hôpital Louis Mourier

    Colombes, 92700, France

  • IRCCS Istituto Tumori Giovanni Paolo II

    Bari, 70124, Italy

  • Ikazia Ziekenhuis

    Rotterdam, 3083 AN, Netherlands

  • International University of Health and Welfare MITA Hospital

    Tokyo, 108-8329, Japan

  • Istituto Clinico Humanitas

    Rozzano, 20089, Italy

  • Istituto Nazionale Tumori Fondazione G. Pascale

    Naples, 80131, Italy

  • Jeonbuk National University Hospital

    Jeonju, 54907, South Korea

  • Jewish General Hospital

    Montreal, Quebec, H3T-1E2, Canada

  • Jiangsu Province Hospital

    Nanjing, 210029, China

  • Jilin Province Tumor Hospital

    Ch’ang-ch’un, 130012, China

  • Juntendo University Hospital

    Tokyo, 113-8421, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Klinikum der Universitaet Muenchen

    München, 80336, Germany

  • Kobe University Hospital

    Kobe, 650-0017, Japan

  • Koo Foundation Sun Yat-Sen Cancer Center

    Taipei, 112, Taiwan

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kyorin University Hospital

    Tokyo, 181-8611, Japan

  • Kyoto University Hospital

    Kyoto, 606-8507, Japan

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • LK Wiener Neustadt

    Neustadt, 2700, Austria

  • LKH - Universitätsklinikum Graz

    Graz, 8010, Austria

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA, Netherlands

  • Liepaja Regional Hospital

    Liepāja, LV3414, Latvia

  • Lipson Cancer Institute

    Rochester, New York, 14621, United States

  • Länssjukhuset Sundsvall-Härnösand

    Sundsvall, 85186, Sweden

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • MD Anderson Cancer Centre

    Madrid, 28033, Spain

  • Markhot Ferenc Oktatokorhaz es Rendelointezet

    Eger, H-3300, Hungary

  • Masarykuv onkologicky ustav

    Brno, 65653, Czechia

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • McGill University Health Centre

    Québec, H4A 3J1, Canada

  • Meander Medisch Centrum

    Amersfoort, 1066 EC, Netherlands

  • Meander Medisch Centrum

    Amersfoort, 3813, Netherlands

  • Medical University of Vienna

    Vienna, 1090, Austria

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10021-0005, United States

  • Memorial Sloan Kettering Cancer Center-Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Cancer Center-Middletown

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Cancer Center-West Harrison

    Harrison, New York, 10604, United States

  • Mie University Hospital

    Mie, 514-8507, Japan

  • Monash Medical Centre Clayton

    Clayton, Victoria, 3168, Australia

  • Msdyrt Midericordiae University Hospital

    Dublin, Ireland

  • Myongji Hospital

    Goyang-si, Gyeonggi-do, 10475, South Korea

  • Nanfang Hospital of Southern Medical University

    Guangzhou, 510515, China

  • Nanjing First Hospital

    Nanjing, 210006, China

  • National Cancer Center Hospital

    Tsukiji, Tokyo, 104-0045, Japan

  • National Cheng Kung University Hospital

    Tainan, 70403, Taiwan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • Nemocnice Na Pleši s.r.o.

    Nová Ves pod Pleší, 26204, Czechia

  • Niagara Health System

    Saint Catharines, Ontario, L2S 0A9, Canada

  • NorthShore University Health System

    Evanston, Illinois, 60201, United States

  • Northern Health

    Epping, Victoria, 3076, Australia

  • Nouvel Hôpital Civil de Strasbourg

    Strasbourg, 67091, France

  • Okayama Medical Center

    Okayama, 7011192, Japan

  • Onkologická klinika VFN a 1. LF UK

    Prague, 128 08, Czechia

  • Onze Lieve Vrouwe Gasthuis, Locatie Oost

    Amsterdam, 1091 AC, Netherlands

  • Onze Lieve Vrouwe Gasthuis, Locatie Oost

    Amsterdam, 1091, Netherlands

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Ospedale Civile Dell Annunziata

    Cosenza, 87100, Italy

  • Ospedale Degli Infermi

    Faenza, 48018, Italy

  • Ospedale SS. Giovanni e Paolo

    Venezia, 30122, Italy

  • Ospedale San Bortolo di Vicenza

    Vicenza, 36100, Italy

  • Ospedale Santa Maria di Cà Foncello

    Treviso, 35128, Italy

  • Ospedalemichele e Pietro ferrer

    Verduno, 12060, Italy

  • Ottawa Hospital

    Ottawa, Ontario, K1H BL6, Canada

  • Pauls Stradins Clinical University Hospital

    Riga, LV-1002, Latvia

  • Peking University Third Hospital

    Beijing, 100191, China

  • Perth Blood Institute

    Perth, 6005, Australia

  • Praxis für Gefäßmedizin

    Görlitz, 2827, Germany

  • Presidio Ospedaliero di Castelfranco Veneto

    Castelfranco Veneto, 31033, Italy

  • Queen Elizabeth II Health Sciences Centre

    Nova Scotia, B3H 2Y9, Canada

  • Queen Elizabeth University Hospital Campus

    Glasgow, SCO, G514TF, United Kingdom

  • Radboud Universitair Medisch Centrum

    Nijmegen, 6525, Netherlands

  • Rode Kruis Ziekenhuis

    Beverwijk, 1942, Netherlands

  • SS. ma Annunziata

    Chieti, 66100, Italy

  • Sault Area Hospital

    Sault Ste. Marie, Ontario, P6A 0A8, Canada

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • SoonChunHyang University Hospital Bucheon

    Bucheon-si, 14584, South Korea

  • Soonchunhyang University Seoul Hospital

    Seoul, 4401, South Korea

  • Soonchunhyang University Seoul Hospital

    Yongsan, 04401, South Korea

  • Southern Medical University - Zhujiang Hospital

    Guangdong, 510280, China

  • Spaarne Gasthuis (Kennemer Gasthuis) - Haarlem-Zuid

    Hoofddorp, 2134TM, Netherlands

  • Staedtisches Klinikum Dresden Standort Dresden-Friedrichstadt

    Dresden, 1067, Germany

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Tergooiziekenhuizen, Hilversum

    Hilversum, 1213, Netherlands

  • The Alfred Hospital

    Prahran, 3181, Australia

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The Newcastle Upon Tyne Hospitals

    Newcastle upon Tyne, ENG, NE7 7DN, United Kingdom

  • The Sixth Affiliated Hospital of Sun Yat-Sen University

    Guangzhou, 510655, China

  • Thomayerova nemocnice

    Prague, 14059, Czechia

  • Tohoku University Graduate School of Medicine

    Miyagi, 980-8574, Japan

  • Tokai University Hospital

    Isehara, 259-1193, Japan

  • Tokyo Saiseikai Central Hospital

    Minatoku, 108-0073, Japan

  • Tongji Hospital, Tongji Medical College

    Wuhan, 430030, China

  • Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • Tri-Service General Hospital

    Taipei, 114, Taiwan

  • Union Hospital Tongji Medical College Huazhong University of Science &Technology

    Wuhan, 430023, China

  • Universit degli Studi di Perugia - Azienda Ospedaliera di Perugia

    Perugia, 6132, Italy

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    Dresden, 1307, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum Magdeburg A.oe.R

    Magdeburg, 39120, Germany

  • Universitair Medisch Centrum Groningen

    Groningen, 9713, Netherlands

  • University Hospital Hradec Kralove

    Hradec Králové, 50005, Czechia

  • University Hospital of Wales

    Cardiff, England, CF14 4XW, United Kingdom

  • University Hospital, Limerick

    Limerick, V94 T9PX, Ireland

  • University Hospitals of North Midlands

    Stafford, England, ST16 3SA, United Kingdom

  • University Hospitals of North Midlands

    Stoke-on-Trent, England, ST4 6QG, United Kingdom

  • University of Alberta Hospital

    Edmonton, Alberta, T6G2V2, Canada

  • University of Calgary

    Calgary, Alberta, T2N 1N4, Canada

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • University of Kentucky, Markey Cancer Center

    Lexington, Kentucky, 40536-0093, United States

  • University of Miami Health

    Miami, Florida, 33136, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pennsylvania - Penn Blood Disorders Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Texas Mays Cancer Center

    San Antonio, Texas, 78229, United States

  • University of Zürich

    Zurich, 8091, Switzerland

  • Università dell'Insubria

    Varese, 21100, Italy

  • Universitätsklinik Leipzig

    Leipzig, 4103, Germany

  • Universitätsklinik der Christian-Albrechts-Universität

    Kiel, 24105, Germany

  • VA Connecticut Healthcare System

    West Haven, Connecticut, 06516-5907, United States

  • Washington DC VAMC

    Washington D.C., District of Columbia, 20422, United States

  • Washington University

    St Louis, Missouri, 63110, United States

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

  • Yokohama Minami Kyosai Hospital

    Kanagawa, 236-0037, Japan

  • Yongin Severance Hospital, Yonsei University Health System

    Yongin-si, Gyeonggi-do, 16995, South Korea

  • Østfold Hospital Kalnes

    Fredrikstad, 1603, Norway

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