Migraine device trial halted early – what we know

NCT ID NCT05843721

Terminated Symptom relief Sponsor: Chordate Medical Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study followed 98 people with chronic migraine who used a device that delivers gentle oscillations inside the nose. The goal was to see if regular use could cut down on severe headache days. The trial was terminated early, so the full results are not available, but the approach aimed to provide a non-drug option for migraine relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intranasal kinetic oscillation stimulation device
What this could lead to: If effective, this device could offer a drug-free option to reduce migraine days for people with chronic migraine.
What could go wrong: The study was terminated early, so results are limited. It was also an uncontrolled trial, making it hard to know if benefits came from the device or chance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MIGRAINE

Contacts and locations

Locations

Centro Regionale Diagnosi e Cura delle Cefalee IRCCS National Neurological Institute "C. Mondino" Foundation

Pavia, 27100, Italy
Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital

Glasgow, G51 4TF, United Kingdom
Hull Royal Infirmary, Hull University Teaching Hospital NHS Trust

Hull, HU3 2J, United Kingdom
IRCCS Istituto Auxologico Italiano U.O. Neurologia - Centro Cefalee

Milan, 20149, Italy
IRCCS San Raffaele Pisana Dipartimento di Scienze Neurologiche Motorie e Sensoriali Unità per la Cura e la Ricerca su Cefalee e Dolore

Roma, 00166, Italy
Kopfschmerzzentrum Frankfurt

Frankfurt am Main, D-65929, Germany
Policlinico Universitario Campus Bio-Medico di Roma UOC Neurologia

Roma, 00128, Italy
Shaare Zedek Medical Center, Neurology Clinics,

Jerusalem, 9103102, Israel
St. George's University Hospitals NHS Foundation Trust

London, SW17 0QT, United Kingdom
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden UniversitätsSchmerzCentrum

Dresden, D-01307, Germany
Universitätsklinikum Essen (AöR) Klinik für Neurologie Kopfschmerz- und Schwindelambulanz

Essen, D-45147, Germany
Universitätsklinikum Tübingen Klinik für Neurologie

Tübingen, D-72076, Germany

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