Experimental heart slicing procedure tested on one patient
NCT ID NCT06269640
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tested a new procedure called SESAME that uses a wire threaded through blood vessels to slice away excess heart muscle in people with hypertrophic cardiomyopathy. Only one adult participated before the study was terminated. The goal was to see if the technique could safely reduce blockage of blood flow from the heart.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Septal Scoring Along Midline Endocardium (SESAME) device
What this could lead to
If refined, this could offer a less invasive alternative to open-heart surgery for reducing thickened heart muscle and improving blood flow.
What could go wrong
This was a very early feasibility study with only 1 participant and was terminated. The procedure carries serious risks like stroke, heart damage, or need for a pacemaker.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Emory University Hospital
Atlanta, Georgia, 30322, United States