Botulinum injection trial for arm spasticity halted early

NCT ID NCT04815967

Terminated Disease control Sponsor: Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants but was terminated early after only 32 people joined. Researchers measured changes in muscle tone and overall function four weeks after a single injection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MYOBLOC (rimabotulinumtoxinB, botulinum toxin type B)
What this could lead to: If it works, this could offer a treatment option to reduce muscle stiffness and improve arm function in people with spasticity from stroke, brain injury, or multiple sclerosis.
What could go wrong: The trial was terminated early with only 32 participants, so results are limited. Botulinum toxin injections can cause muscle weakness, pain, or allergic reactions, and effects are temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic cerebral palsy hemiplegia multiple sclerosis Muscle Spasticity spastic cerebral palsy spinal cord injury stroke disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBRAL PALSY CEREBROVASCULAR ACCIDENT CERVICAL SPINAL CORD INJURY MULTIPLE SCLEROSIS SPASTICITY TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Centrum Medyczne Linden

Krakow, 31-721, Poland
Coastal Neurology

Port Royal, South Carolina, 29935, United States
Idaho Physical Medicine and Rehabilitation

Boise, Idaho, 83706, United States
National Institute of Medical Rehabilitation

Budapest, H-1121, Hungary
Niepubliczny Zaklad Opieki Zdrowotnej (NZOZ) Neuromed

Lubin, 20-604, Poland
Rancho Research Institute

Downey, California, 90242, United States
Specjalistyczna Praktyka Lekarska

Katowice, 40-097, Poland
Specjalistyczne Gabinety Sp. zo.o

Krakow, 30-539, Poland
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

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