Cholesterol drug tested to stop dangerous pregnancy complication
NCT ID NCT03944512
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether the cholesterol-lowering drug pravastatin could prevent preeclampsia in women who had a previous early preterm delivery due to the condition. The trial planned to enroll 1,550 women but was terminated early with only 102 participants. Because it stopped early, the results are not strong enough to draw clear conclusions about whether pravastatin helps or is safe in pregnancy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pravastatin (a statin drug, typically used for cholesterol)
What this could lead to
If it had worked, this could have pointed toward a way to prevent preeclampsia in women at high risk, potentially saving lives and preventing complications.
What could go wrong
The trial was terminated early with only 102 participants instead of the planned 1,550, so results are very limited and not reliable. Statins are generally not recommended in pregnancy due to safety concerns.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brown University
Providence, Rhode Island, 02905, United States
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Case Western Reserve-Metro Health
Cleveland, Ohio, 44109, United States
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Columbia University
New York, New York, 10032, United States
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Magee Women's Hospital of UPMC
Pittsburgh, Pennsylvania, 15213, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Hospital
Columbus, Ohio, 43210, United States
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University of Alabama - Birmingham
Birmingham, Alabama, 35233, United States
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University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Texas - Houston
Houston, Texas, 77030, United States
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University of Texas Medical Branch
Galveston, Texas, 77555, United States
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University of Utah Medical Center
Salt Lake City, Utah, 84132, United States