Sound waves and microbubbles aim to boost heart attack clot treatment
NCT ID NCT04217304
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested whether using ultrasound and microbubbles (sonothrombolysis) alongside standard clot-busting drugs could help restore blood flow in people having a severe heart attack. The study planned to enroll 41 participants but was terminated early. The main goal was to check safety and whether the treatment improved heart electrical activity, a sign of better blood flow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Definity® (microbubbles) with high mechanical index ultrasound
What this could lead to
If it works, this could improve blood flow restoration in heart attack patients receiving clot-busting drugs, potentially reducing heart damage.
What could go wrong
This was a small, early-phase trial that was terminated, so results are limited. The approach adds complexity and may not improve outcomes over standard care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Alberta
Edmonton, Alberta, Canada