Inhaled treprostinil safety trial for PH-COPD ends early

NCT ID NCT03794583

Terminated Disease control Sponsor: United Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the long-term safety of an inhaled drug called treprostinil in people who have both pulmonary hypertension (high blood pressure in the lungs) and COPD. It included 41 adults who had already completed a previous study. The trial was terminated early, and the main goal was to track side effects. Results may help understand if this treatment is safe to use over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: inhaled treprostinil
What this could lead to: If successful, this could support the use of inhaled treprostinil as a safe long-term treatment for pulmonary hypertension related to COPD.
What could go wrong: The study was terminated early with only 41 participants, so results are limited. It was an open-label extension, meaning no placebo group for comparison, and safety data may not be conclusive.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease hypertensive disorder lung disorder pulmonary hypertension pulmonary hypertension owing to lung disease and/or hypoxia vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE PULMONARY HYPERTENSION

Contacts and locations

Locations

"Azienda Unita Sanitaria Locale Della Romagna Ospedale ""Gian Battista Morgagni"" - Luigi Pierantoni"" di Forli"

Forlì, Forli, 47121, Italy
Albany Medical Center

Albany, New York, 12208, United States
Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Carilion Clinic

Roanoke, Virginia, 24014, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Georgia Clinical Research

Austell, Georgia, 30106, United States
Hadassah-Hebrew University Hospital

Jerusalem, 9112001, Israel
Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States
Kentuckiana Pulmonary Associates

Louisville, Kentucky, 40202, United States
Lady Davis Carmel Medical Centre

Haifa, 34362, Israel
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital at Gulfport

Gulfport, Mississippi, 39501, United States
Mount Sinai Medical Center

New York, New York, 10029, United States
Pulmonary & Critical Care of Atlanta

Atlanta, Georgia, 30342, United States
Pulmonary Associates of Richmond, Inc.

Richmond, Virginia, 23230, United States
Rabin Medical Center

Petah Tikva, 4941492, Israel
Spectrum Health

Grand Rapids, Michigan, 49546, United States
St. Francis Sleep Allergy & Lung Institute

Clearwater, Florida, 33765, United States
St. Vincent Medical Group, Inc.

Indianapolis, Indiana, 46260, United States
St. Vincent's Lung, Sleep, and Criticial Care Specialists

Jacksonville, Florida, 32204, United States
The Carl and Edyth Lindner Research Center at The Christ Hospital

Cincinnati, Ohio, 45219, United States
The University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California Davis Medical Center

Sacramento, California, 95817, United States
University of Illinois Medical Center

Chicago, Illinois, 60612, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Miami Hospital

Miami, Florida, 33136, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Medical Center

Rochester, New York, 14623, United States
University of Wisconsin School of Medicine and Public Health

Madison, Wisconsin, 53792, United States

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