Could a cream replace pills for painful birthmarks? early trial hints at possibility

NCT ID NCT04172922

Terminated Disease control Sponsor: Nemours Children's Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-phase study tested a sirolimus (rapamycin) cream applied directly to skin lesions in children with vascular anomalies. The goal was to see if the cream could safely reduce pain, bleeding, and lesion size without the side effects of oral medication. Only 5 children were enrolled, and the study was terminated early, so the results are very preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: topical sirolimus (rapamycin) cream
What this could lead to: If it works, this could offer a safer, skin-only treatment for painful or bleeding vascular lesions in children, avoiding the side effects of oral medication.
What could go wrong: This was a very small, early-phase trial that was terminated early, so results are limited. Topical sirolimus may not work for all types of vascular anomalies, and long-term safety is not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

vascular malformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VASCULAR ANOMALY

Contacts and locations

Locations

Nemours Children's Health, Jacksonville

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital, Florida

Orlando, Florida, 32827, United States

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