Small study tests best epinephrine dose for kids in crisis

NCT ID NCT05327556

Terminated Disease control Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study compared two different doses of epinephrine (0.5 vs 1.0 mcg/kg) given to children in the intensive care unit for life-threatening low blood pressure. The goal was to see which dose raised blood pressure more effectively. Only 15 children were enrolled before the study was stopped early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: epinephrine
What this could lead to: If successful, this could help doctors choose the best dose of epinephrine to quickly raise blood pressure in critically ill children.
What could go wrong: This was a very small, early-phase trial that was terminated early, so results are limited. It only looked at short-term blood pressure changes, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTENSION

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

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