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New drug aims to help lungs and heart work better during exercise

NCT ID NCT04084678

Terminated Disease control Sponsor: United Therapeutics Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether ralinepag, an oral medication, can improve exercise capacity in people with pulmonary arterial hypertension (PAH) who have recently started PAH therapy. Participants take ralinepag or a placebo for 28 weeks, and their peak oxygen consumption during exercise is measured. The study focuses on safety and how well the drug helps the heart and lungs work during physical activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Ralinepag (oral drug)
What this could lead to
If successful, ralinepag could become a new treatment option to improve exercise ability and daily function in people with pulmonary arterial hypertension.
What could go wrong
This is a small, early-phase study, and results may not confirm benefit. Side effects or lack of improvement in exercise capacity are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension pulmonary hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY ARTERIAL HYPERTENSION PULMONARY HYPERTENSION

Contacts and locations

Locations

  • AKH Wien, Innere Med. II, Kardiologie

    Vienna, 1090, Austria

  • AOU Policlinico Umberto I

    Rome, 00161, Italy

  • Banner University Medical Center (University of Arizona)

    Tucson, Arizona, 85724, United States

  • Centro Cardiologico Monzino, IRCCS

    Milan, 20138, Italy

  • Centro de Hipertensão Pulmonar

    Porto Alegre, 90035074, Brazil

  • Erasme University Hospital - Department of Cardiology

    Brussels, 1070, Belgium

  • Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Oddział Kardiologiczny

    Otwock, 05-400, Poland

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Gasthuisberg University Hospital - Department of Pulmonology

    Leuven, 3000, Belgium

  • Hospital Britanico de Buenos Aires

    Ciudad Autónoma de Bs. As., 1280, Argentina

  • Hospital Clínic I Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Madre Teresa

    Belo Horizonte, Minas Gerais, 30441-070, Brazil

  • Hospital Sao Paulo

    São Paulo, São Paulo, 04037-002, Brazil

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Imperial college Healthcare NHS Trust

    London, W12 0HS, United Kingdom

  • Instituto de Cardiología de Corrientes

    Corrientes, W3400AMZ, Argentina

  • Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo - InCor-HCFMUSP

    São Paulo, São Paulo, 05403-000, Brazil

  • London Health Science Centre- Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • Macquarie University

    North Ryde, New South Wales, 2109, Australia

  • Medical College of Wisconsin/Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • Ordensklinikum Linz GmbH, Elisabethinen

    Linz, 4020, Austria

  • Peter Lougheed Center

    Calgary, Alberta, T1Y 6J4, Canada

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Tampa General Hospital/University of South Florida Center for Advanced Lung Disease and Lung Transplant

    Tampa, Florida, 33606, United States

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

  • Thoraxklinik-Heidelberg, Zentrum für Pulmonale Hypertonie

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • Universitätsklinikum Carl Gustav Carus TU Dresden, Medizinische Klinik I, Abteilung für Pneumologie

    Dresden, Saxony, 01307, Germany

  • Uniwersytecki Szpital Kliniczny w Białymstoku, Klinika Kardiologii z Oddziałem Intensywnego Nadzoru Kardiologicznego

    Bialystok, 15-276, Poland

  • Westmead Hospital, Dept Respiratory and Sleep Medicine

    Westmead, New South Wales, 2145, Australia

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