Promising preeclampsia drug trial halted early – what happened?

NCT ID NCT03008616

Terminated Disease control Sponsor: AMAG Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called AMAG-423 (Digoxin Immune Fab) in pregnant women with severe preeclampsia, a dangerous condition of high blood pressure during pregnancy. The goal was to see if the drug could reduce serious health problems in babies, such as bleeding in the brain or bowel issues, and improve kidney function in mothers. The trial was stopped early after enrolling 58 participants, so results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

preeclampsia severe pre-eclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE PREECLAMPSIA

Contacts and locations

Locations

Adalbertus Hospital

Gdansk, Pomeranian Voivodeship, 80-462, Poland
Baylor Scott & White Health

Temple, Texas, 76508, United States
Children's Hospital Foundation Building

Louisville, Kentucky, 40202, United States
Detroit Medical Center (DMC)

Detroit, Michigan, 48201, United States
Louisiana State University Health Sciences Center in New Orleans

New Orleans, Louisiana, 70112, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Regional Obstetrical Consultants

Chattanooga, Tennessee, 37403, United States
Sefako Makgatho Health Sciences University

Pretoria, Gauteng, 0204, South Africa
Texas Children's Hospital/Baylor College of Medicine

Houston, Texas, 77030, United States
The University of Texas Health Science Center at Houston (UTHSC-H)

Houston, Texas, 77303, United States
The University of Texas Medical Branch (UTMB)

Galveston, Texas, 77555, United States
University Hospitals Case Medical Center-Case Western Reserve University (CWRU)

Cleveland, Ohio, 44106, United States
University Of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of South Alabama

Mobile, Alabama, 36604, United States
University of Virginia School Of Medicine

Charlottesville, Virginia, 29208, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.