Why does labetalol fail in severe preeclampsia? new study aims to find out

NCT ID NCT07547046

Not yet recruiting Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

Severe preeclampsia is a dangerous pregnancy complication that can cause high blood pressure, harming both mother and baby. This observational study will follow 350 women to identify factors that make blood pressure control with the drug labetalol fail. By understanding these factors, doctors hope to predict treatment failure and adjust care more quickly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: labetalol
What this could lead to: If successful, this study could help doctors identify which women with severe preeclampsia are less likely to respond to labetalol, allowing for faster, more personalized treatment.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new therapy. It may only identify associations, not causes, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

preeclampsia severe pre-eclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE PREECLAMPSIA

Contacts and locations

Locations

CH Agen-Nerac

Nérac, France
CH de Roubaix

Roubaix, France
CHRU Nancy

Nancy, France
CHU Bordeaux

Bordeaux, France
CHU Carémeau

Nîmes, France
CHU Clermont-Ferrand

Clermont-Ferrand, France
CHU Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant

Lyon, France
CHU Lille

Lille, France
CHU Martinique

Martigues, France
Hôpital Antoine Béclère

Clamart, France
Hôpital Armand-Trousseau

Paris, France
Hôpital Bicêtre

Le Kremlin-Bicêtre, France
Hôpital Cochin Port Royal

Paris, France
Hôpital Necker

Paris, France

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