HIV cancer hope: immune combo shows early promise but trial halted
NCT ID NCT02408861
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested two immunotherapy drugs, ipilimumab and nivolumab, in people with HIV who had advanced solid tumors or Hodgkin lymphoma that had spread or come back. The goal was to find the safest dose and see if the combination could shrink tumors. The study was terminated early, so full results are not available, but the approach aims to boost the immune system to fight cancer in a vulnerable population.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ipilimumab and nivolumab (immunotherapy antibodies)
- What this could lead to
- If it works, this could offer a new treatment option for people with HIV who have certain advanced cancers that are hard to treat.
- What could go wrong
- This was a very early (phase I) trial that was terminated, so results are limited. The combination may cause serious immune-related side effects, and it is unclear if it will work for all HIV-associated cancers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
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Benaroya Research Institute at Virginia Mason
Seattle, Washington, 98101-2795, United States
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FHCC South Lake Union
Seattle, Washington, 98109, United States
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George Washington University Medical Center
Washington D.C., District of Columbia, 20037, United States
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Harborview Medical Center
Seattle, Washington, 98104, United States
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John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
East White Plains, New York, 10604, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
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Montefiore Medical Center-Weiler Hospital
The Bronx, New York, 10461, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Pennsylvania Hospital
Philadelphia, Pennsylvania, 19107, United States
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Saint Vincent's Hospital
Darlinghurst, New South Wales, 2010, Australia
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Siteman Cancer Center at Washington University
St Louis, Missouri, 63110, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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UC San Diego Medical Center - Hillcrest
San Diego, California, 92103, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UCLA Center for Clinical AIDS Research and Education
Los Angeles, California, 90035, United States
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UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
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UCSF Medical Center-Parnassus
San Francisco, California, 94143, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of New South Wales
Sydney, New South Wales, 2052, Australia
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University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
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Virginia Mason Medical Center
Seattle, Washington, 98101, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Zuckerberg San Francisco General Hospital
San Francisco, California, 94110, United States
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