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Psychedelics rewire Brain's learning? yale study investigates

NCT ID NCT06624137

Terminated Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's information processing, such as reliance on new versus old information, and electrical activity. Participants will complete computer tasks, brain scans (MEG/EEG/MRI), and interviews to track these changes over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how psychedelics alter brain processing, potentially guiding better treatments for mental health conditions and predicting who might benefit or experience side effects.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test a therapy. Results may be complex and not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse Behavior, Addictive combat disorder major depressive disorder migraine disorder nicotine dependence obsessive-compulsive disorder obsessive-compulsive personality disorder opiate dependence post-traumatic stress disorder substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADDICTION ALCOHOL USE DISORDER (AUD) HEALTHY VOLUNTEER MAJOR DEPRESSIVE DISORDER (MDD) MIGRAINE OBSESSIVE COMPULSIVE DISORDER (OCD) OCD OPIOID-USE DISORDER PTSD PTSD - POST TRAUMATIC STRESS DISORDER TOBACCO USE DISORDER

Contacts and locations

Locations

  • Connecticut Mental Health Center

    Hamden, Connecticut, 06517, United States

  • West Haven VA Medical Center

    West Haven, Connecticut, 06516, United States

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