Spinal tap could replace brain surgery for young tumor patients

NCT ID NCT05934630

Terminated Knowledge-focused Sponsor: Pediatric Brain Tumor Consortium Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring. Up to 300 participants provided extra fluid samples during routine care, and their results were compared with tumor tissue samples.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANAPLASTIC ASTROCYTOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

anaplastic astrocytoma anaplastic oligodendroglioma astrocytoma (excluding glioblastoma) atypical teratoid rhabdoid tumor brain cancer brain stem glioma central nervous system cancer central nervous system germ cell tumor choroid plexus carcinoma diffuse leptomeningeal glioneuronal tumor ependymoma fibrillary astrocytoma glioblastoma glioma susceptibility 1 high grade astrocytic tumor medulloblastoma oligodendroglioma pilocytic astrocytoma Pinealoma pineoblastoma rhabdoid tumor supratentorial primitive neuroectodermal tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAPLASTIC ASTROCYTOMA ANAPLASTIC OLIGODENDROGLIOMA ATYPICAL TERATOID/RHABDOID TUMOR CHOROID PLEXUS CARCINOMA CNS GERM CELL TUMOR CNS PRIMARY TUMOR, NOS DIFFUSE BRAINSTEM GLIOMA DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR EPENDYMOMA, NOS FIBRILLARY ASTROCYTOMA GLIOBLASTOMA MULTIFORME HIGH-GRADE ASTROCYTOMA NOS LOW-GRADE ASTROCYTOMA, NOS MEDULLOBLASTOMA OLIGODENDROGLIOMA, NOS PILOCYTIC ASTROCYTOMA PINEOBLASTOMA SUPRATENTORIAL PRIMITIVE NEUROECTODERMAL TUMOR

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Children's Hospital of Los Angeles

Los Angeles, California, 90026, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Childrens Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Hospital for Sick Children

Toronto, Ontario, M5G1X8, Canada
Lucille Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Nationwide Childrens Hospital

Columbus, Ohio, 43205, United States
Texas Children's Hospital

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.