Pediatric Brain Tumor Consortium

This early-stage study is testing a new antibody drug called APX005M in children and young adults with brain tumors that have come back or are not responding to treatment, or with a newly diagnosed aggressive brain stem glioma. The main goal is to find the safest dose and underst…

This study is testing whether adding the drug hydroxychloroquine to two other targeted cancer drugs can better control brain tumors in children and young adults. It is for patients whose tumors have grown back or progressed despite previous similar treatments and who have specifi…

This study is testing a new combination treatment for children and young adults whose brain tumors have come back. It adds a targeted radiation drug, delivered directly into the fluid around the brain, to standard chemotherapy. The main goals are to see if this approach helps pat…

This trial aimed to test an experimental virus therapy called G207 for children whose aggressive brain tumors had returned. The virus is designed to infect and kill cancer cells while sparing healthy ones. Doctors planned to inject the virus directly into the tumor and follow it …