Pediatric Brain Tumor Consortium

This study tests a new treatment for children whose medulloblastoma or ependymoma has come back. It combines a specially designed antibody that delivers radiation directly into the brain fluid with standard chemotherapy drugs. The goal is to see if this approach can help children…

This study tests whether adding hydroxychloroquine (a malaria drug) to targeted cancer drugs (dabrafenib and/or trametinib) can help children and young adults with certain brain tumors that have come back or not responded to previous treatment. Participants must have tumors with …

This study was designed for children with a type of aggressive brain cancer (high-grade glioma) that has come back after initial treatment. It planned to test an experimental virus therapy, G207, injected directly into the tumor, along with a single dose of radiation. The goal wa…

This early-stage trial tests the safety and best dose of a drug called APX005M in 32 children whose brain tumors have come back or are hard to treat, including a type of brain stem tumor called DIPG. The drug works by activating the immune system to attack cancer cells. The main …