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Heart surgery drug may keep blood pressure steady

NCT ID NCT02675374

Symptom relief Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a drug called Polaramine can prevent dangerous drops in blood pressure when patients come off a heart-lung machine during aortic valve replacement. 18 adults took part. The goal was to see if the drug helps the body keep a stable blood pressure after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

18 people

The number who actually took part.

Started

Jun 2016

Finished

Jul 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men aged 18 and older * Post menopausal women * Patients scheduled for an aortic valve replacement with a traditional sternotomy and CPB Exclusion Criteria: * Patients with a left ventricular ejection fraction lower than 40% * Patients with pulmonary arterial hypertension higher than 50mm of Hg, * Redo cardiac surgery, * Atrioventricular and intraventricular conduction disturbances * Epilepsy or convulsions * Atopic disease * Women of childbearing potential * Patients at risk of glaucoma * Patients with therapy interacting with dexchlorpheniramine (Polaramine®). * Patients unable to provide a signed informed consent

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Conditions

The condition(s) this trial relates to.

aortic valve disorder Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodynamic instability Vasoplegic syndrome

Contacts and locations

Locations

  • CHU de Bordeaux

    Pessac, 33604, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.