New antibody aims to shield kidneys from autoimmune attack

NCT ID NCT06047171

Recruiting now Disease control Sponsor: Alentis Therapeutics AG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This Phase 2 trial tests whether adding ALE.F02 to standard therapy can protect kidney function in people with ANCA-associated vasculitis, an autoimmune disease that attacks small blood vessels, often damaging the kidneys. About 80 participants will receive either a low, high, or maximum dose of ALE.F02, or a placebo, alongside standard treatment. The study focuses on safety and whether the drug helps preserve kidney function over 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALE.F02 (a monoclonal antibody targeting Claudin-1)
What this could lead to: If successful, ALE.F02 could help preserve kidney function in people with ANCA-associated vasculitis, reducing the need for dialysis or transplant.
What could go wrong: This is an early Phase 2 trial with only 80 participants. The drug may not show benefit, or could cause unexpected side effects. It is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS WITH RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

anti-neutrophil cytoplasmic antibody-associated vasculitis rapidly progressive glomerulonephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLOMERULONEPHRITIS RAPIDLY PROGRESSIVE

Contacts and locations

Locations

AP-HM - Hopital de La Conception
ACTIVE_NOT_RECRUITING

Marseille, 13385, France
AP-HP Hopital Cochin
RECRUITING

Paris, 75014, France
AP-HP Hopital Pitie-Salpetriere
RECRUITING

Paris, 75013, France
APSS Ospedale Santa Chiara di Trento
RECRUITING

Trento, 38122, Italy
Aalborg University Hospital
RECRUITING

Aalborg, 9000, Denmark
Aarhus University Hospital
RECRUITING

Aarhus, 8200, Denmark
Ankara Etlik City Hospital
RECRUITING

Ankara, Keçiören, Turkey (Türkiye)
Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
RECRUITING

Bergamo, 24127, Italy
CHRU de Brest - Hopital de la Cavale Blanche
RECRUITING

Brest, 29200, France
CHU Bordeaux - Hopital Pellegrin
RECRUITING

Bordeaux, 33000, France
CHU Grenoble-Alpes - Hopital Michallon
RECRUITING

La Tronche, 38700, France
CHU de Nantes - Hotel-Dieu
RECRUITING

Nantes, 44000, France
CHU de Nimes
RECRUITING

Nîmes, 31000, France
CHU de Toulouse - Hopital Rangueil
RECRUITING

Toulouse, 31400, France
Cambridge University - Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Centre Hospitalier Boulogne sur Mer
RECRUITING

Boulogne-sur-Mer, Cedex, 62200, France
Centre Hospitalier de Valenciennes
RECRUITING

Valenciennes, 59300, France
Charite Universitaetsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Erciyes University Faculty of Medicine
RECRUITING

Melikgazi, Turkey (Türkiye)
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore
RECRUITING

Rome, 00168, Italy
Fundacio Puigvert
RECRUITING

Barcelona, 08025, Spain
Herlev Hospital
ACTIVE_NOT_RECRUITING

Herlev, 2730, Denmark
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29001, Spain
Hospital Universitari Arnau de Vilanova
RECRUITING

Lleida, 25198, Spain
Hospital Universitari de Bellvitge
RECRUITING

Barcelona, 08907, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hôpital Fribourgeois-Freiburger Spital
WITHDRAWN

Villars-sur-Glâne, 1752, Switzerland
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Imperial College Healthcare NHS Trust
RECRUITING

London, W21NY, United Kingdom
Inselspital, Universitaetsspital Bern
RECRUITING

Bern, 3010, Switzerland
Institut klinicke a experimentalni mediciny
RECRUITING

Prague, 140 21, Czechia
Kantonsspital Baden AG
RECRUITING

Baden, 5404, Switzerland
Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, 9000, Switzerland
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
RECRUITING

München, 80802, Germany
Kocaeli University Medical School - Internal Medicine - Nephrology
RECRUITING

Kocaeli, Turkey (Türkiye)
Linkoping University Hospital
RECRUITING

Linköping, 581 85, Sweden
Manchester University NHS Foundation Trust (MFT)
RECRUITING

Manchester, United Kingdom
Marmara University Medical Faculty Hospital
RECRUITING

Istanbul, Turkey (Türkiye)
Medizinische Hochschule Hannover (MHH)
RECRUITING

Hanover, 30625, Germany
Odense University Hospital
RECRUITING

Odense, 5000, Denmark
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, B152GW, United Kingdom
Rigshospitalet
RECRUITING

Copenhagen, 56 2100, Denmark
Royal Free London NHS Foundation Trust
RECRUITING

London, United Kingdom
Royal Liverpool University Hospital
RECRUITING

Liverpool, L78YE, United Kingdom
Royal Preston Hospital
RECRUITING

Preston, PR2 9HT, United Kingdom
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Koeln (AoeR)
RECRUITING

Cologne, 50931, Germany
Universitaetsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
RECRUITING

Lübeck, 23562, Germany
University Hospital of Umea
RECRUITING

Umeå, 907 37, Sweden
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 128 08, Czechia