New shot aims to stop repeat heart sac inflammation

NCT ID NCT07010159

Recruiting now Disease control Sponsor: Kiniksa Pharmaceuticals International, plc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an injected drug called KPL-387 in 165 people with recurrent pericarditis, a condition where the sac around the heart becomes inflamed again and again. The goal is to see if KPL-387 can reduce flare-ups and pain better than a placebo. Participants must have symptoms despite standard treatments like NSAIDs or colchicine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

KPL-387 (injected under the skin)

What this could lead to

If successful, this could provide a new treatment option to control recurrent pericarditis and reduce painful flare-ups.

What could go wrong

This is an early-to-mid stage trial with only 165 participants. The drug may not work better than placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

idiopathic recurrent pericarditis pericarditis Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERICARDITIS PERICARDITIS ACUTE RECURRENT PERICARDITIS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Investigational Site 001
WITHDRAWN

Columbus, Georgia, 31904, United States
Investigational Site 002
WITHDRAWN

Overland Park, Kansas, 66221, United States
Investigational Site 003
RECRUITING

Cleveland, Ohio, 44195, United States
Investigational Site 004
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Chicago, Illinois, 60611, United States
Investigational Site 005
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Austin, Texas, 78705, United States
Investigational Site 006
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Charlottesville, Virginia, 22903, United States
Investigational Site 007
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Milan, 20157, Italy
Investigational Site 008
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San Francisco, California, 94158, United States
Investigational Site 009
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Cincinnati, Ohio, 45219, United States
Investigational Site 010
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Barcelona, 8035, Spain
Investigational Site 011
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Murcia, 30120, Spain
Investigational Site 012
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Rochester, Minnesota, 55905, United States
Investigational Site 013
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Houston, Texas, 77030, United States
Investigational Site 014
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Indianapolis, Indiana, 46184, United States
Investigational Site 015
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New York, New York, 10016, United States
Investigational Site 016
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Westminster, Colorado, 80023, United States
Investigational Site 017
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Southampton, SO17 1BJ, United Kingdom
Investigational Site 018
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Gilbert, Arizona, 85297, United States
Investigational Site 019
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Poitiers, 86000, France
Investigational Site 020
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London, EC1A 7BE, United Kingdom
Investigational Site 021
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Paris, 75013, France
Investigational Site 022
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New York, New York, 10032, United States
Investigational Site 023
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Norfolk, Virginia, 23507, United States
Investigational Site 024
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Madrid, 28850, Spain
Investigational Site 025
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Belgrade, 11000, Serbia
Investigational Site 026
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Belgrade, 11040, Serbia
Investigational Site 027
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Ottawa, Ontario, K1N 6N5, Canada
Investigational Site 028
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Montpellier, 34090, France
Investigational Site 029
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Genoa, 16132, Italy
Investigational Site 030
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Los Angeles, California, 90048, United States
Investigational Site 031
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Warsaw, 02-507, Poland
Investigational Site 032
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Voula, 166 73, Greece
Investigational Site 033
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Udine, 33100, Italy
Investigational Site 034
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Athens, 115 28, Greece
Investigational Site 035
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London, SE1 7EH, United Kingdom
Investigational Site 036
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Pessac, 33600, France
Investigational Site 037
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Toulouse, 31400, France
Investigational Site 038
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Toulouse, 31400, France
Investigational Site 039
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Nea Ionia, 142 33, Greece
Investigational Site 040
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Genoa, 16147, Italy
Investigational Site 041
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Varese, 21100, Italy
Investigational Site 042
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Burlington, Vermont, 05401, United States
Investigational Site 043
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Baltimore, Maryland, 21287, United States
Investigational Site 044
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Santa Monica, California, 90404, United States
Investigational Site 045
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Richmond, Virginia, 23284, United States
Investigational Site 046
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Kansas City, Missouri, 66160, United States
Investigational Site 047
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London, NW3 2QG, United Kingdom
Investigational Site 048
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Barcelona, 08017, Spain
Investigational Site 050
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Kansas City, Missouri, 64111, United States
Investigational Site 050
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Padua, 35143, Italy
Investigational Site 051
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Warsaw, 02-097, Poland
Investigational Site 052
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Dresden, 01069, Germany
Investigational Site 053
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Phoenix, Arizona, 85054, United States
Investigational Site 054
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Boston, Massachusetts, 02411, United States
Investigational Site 055
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Minneapolis, Minnesota, 55407, United States
Investigational Site 056
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Milan, 20132, Italy
Investigational Site 057
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Valencia, 46015, Spain
Investigational Site 058
RECRUITING

Ventura, California, 93003, United States