Could waiting longer to clamp the cord boost outcomes for babies with heart defects?

NCT ID NCT06153459

Recruiting now Disease control Sponsor: Carl Backes, MD Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial asks whether clamping the umbilical cord at 120 seconds after birth is better than clamping at 30 seconds for babies born with congenital heart disease. About 500 infants with a prenatal heart defect diagnosis will be randomly assigned to one of the two timings. Researchers will track health outcomes shortly after birth and check motor and brain development at 3-4 months, 9-12 months, and 22-26 months of age. The goal is to find out which approach gives these babies the best start.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Umbilical cord clamping at 30 seconds vs 120 seconds, or cord milking if early clamping is needed
What this could lead to: If one timing is better, it could become the standard way to manage cord clamping for babies with heart defects, potentially improving survival and brain development.
What could go wrong: This is an early-stage trial, and the best timing may not clearly outperform the other. There are also risks like breathing problems or blood issues that the trial will monitor.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital heart disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEART DISEASE (CHD)

Contacts and locations

Locations

Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Children's Hospital of Orange County
NOT_YET_RECRUITING

Orange, California, 92868, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States
Children's of Mississippi
RECRUITING

Jackson, Mississippi, 39216, United States
Duke Children's Hospital & Health Center
RECRUITING

Durham, North Carolina, 27705, United States
IWK Health Centre
RECRUITING

Halifax, Nova Scotia, Canada
Johns Hopkins Children's Center
RECRUITING

Baltimore, Maryland, 21287, United States
Lucile Packard Children's Hospital Stanford
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Medical University of South Carolina
RECRUITING

Columbia, South Carolina, 29209, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt
RECRUITING

Nashville, Tennessee, 37232, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
SSM Health Cardinal Glennon Children's Hospital
RECRUITING

St Louis, Missouri, 63104, United States
Sharp Mary Birch Hospital for Woman and Newborns
RECRUITING

San Diego, California, 92123, United States
Stollery Children's Hospital, University of Alberta
RECRUITING

Edmonton, Alberta, Canada
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
The Children's Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
The Hospital for Sick Children
NOT_YET_RECRUITING

Toronto, Ontario, Canada
UF Health Shands Children's Hospital
RECRUITING

Gainesville, Florida, 32608, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

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