New heart valve procedure could offer safer alternative to Open-Heart surgery for seniors

NCT ID NCT07453407

Recruiting now Disease control Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults aged 65 and older with severe symptoms or signs of heart strain will be enrolled. Researchers will compare death rates, strokes, and unplanned heart-related hospital stays over one year.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

aortic valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC INSUFFICIENCY AORTIC REGURGITATION AORTIC VALVE INSUFFICIENCY

Contacts and locations

Locations

Beijing Anzhen Hospital Affiliated to Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100000, China
Cheng Hsin General Hospital
NOT_YET_RECRUITING

Taibei, Taiwan, 100-116, China
Fujian Medical University Union Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350000, China
Fuwai Central China Cardiovascular Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450000, China
Fuwai Hospital, Chinese Academy of Medical Sciences
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100000, China
Guangdong Provincial People's Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510000, China
Kunming Yan'an Hospital
NOT_YET_RECRUITING

Kunming, Yunnan, 650000, China
Nanjing First Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210000, China
National Taiwan University Hospital
NOT_YET_RECRUITING

Taibei, Taiwan, 100116, China
Prince of Wales Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong, 999077, China
Qilu Hospital, Shandong University
NOT_YET_RECRUITING

Jinan, Shandong, 250000, China
Queen Mary Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong, 999077, China
Shanghai Chest Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Shanghai East Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Shanghai Geriatric Medical Center
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200000, China
The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITING

Qingdao, Shandong, 266000, China
The First Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITING

Hefei, Anhui, 230000, China
The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310000, China
The Second Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330000, China
The Second Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China
The Second Xiangya Hospital, Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410000, China
Tianjin Chest Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300000, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430000, China
West China Hospital, Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610000, China
Xiangya Hospital, Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410000, China
Xijing Hospital affiliated to Air Force Medical University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710000, China
Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITING

Wuhan, Hubei, 430000, China
Zhongshan Hospital, Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.