CARDIOVASCULAR DISEASES

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation. About 120 adults with AFib will get a small monitor placed under their skin before or during the…

This study looks at how well the Onyx stent works and how safe it is for people with blocked heart arteries. About 4500 adults who need a stent to open a blocked artery are taking part. The goal is to see if the Onyx stent is better than other stents at keeping arteries open and …

This study tests a new device called the Edwards EVOQUE system to replace the tricuspid valve in people with severe leakage. The goal is to see if it safely reduces leakage and improves symptoms like shortness of breath and fatigue. About 864 adults with severe tricuspid regurgit…

This study planned to test a special tube called the Versus Catheter for dissolving blood clots in the lungs. It aimed to see how well the catheter worked and how doctors liked using it. However, the study was withdrawn before any patients were enrolled, so no results are availab…

This study looks at how changing when you eat and improving sleep can help people with type 2 diabetes, high blood pressure, or obesity better control their blood sugar, heart health, and weight. About 40 adults will receive personalized nutrition advice and education. The goal i…

This study tests whether spermidine, a natural substance found in foods like wheat germ and soy, can improve heart and muscle health in people aged 65 and older with coronary artery disease. About 180 participants will receive either spermidine or a placebo for a period, and rese…

This study tested a new device called the Tendyne Transcatheter Mitral Valve System to treat people with a severe leaky heart valve (mitral regurgitation). About 103 participants received either the Tendyne device or another approved device. The goal was to see if the new valve i…

This study tests a clinic-based program called ActivityChoice that helps cancer survivors become more physically active to lower their risk of heart disease. About 114 adult cancer survivors will be offered a choice of group in-person, group virtual, or self-monitored digital exe…

This study looks at whether different levels of exercise can help the hearts of young adults who survived childhood cancer and were treated with a type of chemotherapy called anthracyclines. Twenty survivors between ages 18 and 39 will take part. The goal is to see if exercise ca…

This study looks at whether having extra appointments with a heart specialist at your local doctor's office can help people at high risk for heart, kidney, metabolic, and lung diseases get better treatment. About 138 adults from a previous study will either get these specialist v…

This study compares a new leadless pacemaker (Micra AV) to a traditional pacemaker with wires in 100 patients aged 70 and older who need a pacemaker for heart block. The goal is to see if the leadless device works as well for exercise capacity. Both devices help control heart rhy…

This study tests whether giving stroke patients a more thorough exam—looking at hidden causes like artery stiffness, hidden heart issues, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people admitted to a Swedish hospital for a str…

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with narrowed heart arteries in China. The goal is to see if the new stent keeps arteries open better after a procedure to restore blood flow. Participants receive o…

This large study tests whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and diabetes are being randomly assigned to either a stand…

This study tests a new device called the Aventus Thrombectomy System to safely remove blood clots from the lungs in people with a sudden, severe pulmonary embolism. About 130 adults aged 18 to 80 with symptoms lasting less than two weeks will be enrolled. The goal is to see if th…

This study tests a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can raise blood pressure. About 1,900 adults with uncontrolled high blood pressure will be followed for years to see if the treatment safely and durably lowers…

This study looks at whether eating walnuts can improve cholesterol levels, reduce inflammation, and change gut bacteria in overweight adults aged 45-70 with high cholesterol. Participants eat walnuts for a period, and researchers measure blood lipids, blood pressure, and stool sa…

This study tests a proactive outreach program to help BIPOC adults who smoke quit tobacco. Researchers will use electronic health records to identify smokers and offer culturally tailored support, including counseling and medication. The goal is to reduce smoking rates and relate…

This study tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a common heart valve disease that currently has no medication. About 150 adults with moderate, symptom-free valve narrowing will take colchicine and be monitored with…

This study tested a special stent (a small mesh tube) coated with a drug to treat blocked heart arteries in 591 people in China. The stent is placed during a procedure to open the artery and slowly releases medicine to prevent re-blockage. The goal was to see if the stent is safe…

This study looks at whether eating dark chocolate can improve key markers of heart health, like blood pressure, blood flow, and cholesterol. Researchers at San Diego State University are comparing regular dark chocolate, bloomed dark chocolate, and white chocolate in 45 generally…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who have already been in earlier ralinepag studies will take the drug and be monitored f…

This study tests two different drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in all three main heart arteries. Participants receive state-of-the-art care including imaging and medication. The goal is to see which stent better prevents…

This study tests a new device called the Millipede Ring, which is placed inside the heart to help a leaky mitral valve close better. It is for people with moderate to severe functional mitral regurgitation who still have symptoms despite medication. The study involves only 4 part…

This study tests whether colchicine, a medicine used for gout, can lower inflammation and reduce the risk of heart disease in people with type 1 diabetes. About 100 adults with type 1 diabetes will take either colchicine or a placebo daily for 26 weeks, with an optional extension…

This study tests a device that uses ultrasound to calm overactive kidney nerves, which can help lower blood pressure. About 154 adults with high blood pressure who are already taking two medications will receive either the ultrasound treatment or a fake procedure. The goal is to …

This study is testing a new device called the EVOQUE system to replace a leaky tricuspid valve without open-heart surgery. The goal is to see if it is safe and works well for people with moderate to severe valve leakage who still have symptoms despite medication. About 228 partic…

This study looks at whether a program called Heart Matters can help Black adults in rural eastern North Carolina lower their blood pressure. The program is run by community leaders and focuses on people with risk factors like high blood pressure or obesity. Researchers will compa…

This study tests an inhaled medicine called mosliciguat in 135 people who have high blood pressure in their lungs due to scarring lung disease. The goal is to see if it improves blood flow and walking ability over 16 weeks. Participants are randomly assigned to receive the drug o…

This study tests a device that removes blood clots from the lungs of people with acute pulmonary embolism. About 125 adults with recent symptoms and evidence of heart strain will be enrolled. The goal is to see if the procedure safely improves heart function and reduces serious c…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study looks at whether heavy smokers at high risk for lung cancer can be screened every two years instead of every year with low-dose CT scans, without missing early-stage cancers. It also offers a smoking cessation program to help participants quit. The goal is to make lung…

This study looks at whether fluid from the skin (dermal interstitial fluid) can be used to find early signs of heart disease, instead of or alongside blood tests. Researchers will take samples from 30 people—some with chronic heart failure and some healthy young adults—to see if …

This study tested whether a risk score based on health records can help find people with hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors used a remote ECG monitor at home. The g…

This study checks if a special blood pressure monitor (BPM Core) can correctly identify an irregular heartbeat called atrial fibrillation. Researchers compared the device's readings to a standard 12-lead ECG in 160 adults. The goal is to see if this easy-to-use home device can he…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis lower their risk of heart disease. About 520 adults aged 40-75 who are not already on cholesterol medication will receive support to manage risk factors like high cholester…

This study tests whether personalized counseling can help prevent high blood pressure in adults living in slums in Dhaka, Bangladesh. 1,700 healthy adults will receive 20 counseling sessions focused on exercise, diet, and avoiding tobacco and alcohol. Researchers will measure cha…

This study compares using a CT scan of the heart arteries versus standard risk scores to guide treatment in people aged 40-70 with risk factors like high blood pressure, diabetes, or smoking. The goal is to see if the CT scan approach reduces deaths from heart disease and non-fat…

This study tests a nurse-led group education program designed to improve sexual function, mood, and quality of life in women attending cardiac rehabilitation after a heart event. About 66 women will take part, and the program is added to their usual rehab care. The goal is to see…

This study tests whether a structured exercise program can improve physical function and reduce disability in HIV-positive adults over 50 in Ivory Coast. Participants are randomly assigned to a supervised group exercise, a home-based program with phone support, or health educatio…

This study tests whether a 4-week smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in 106 stressed adults aged 45 and older who are at risk for heart disease. Participants are randomly assigned to either the mindfulness app (with d…

This study tracks over 800 heart failure patients in Germany who are starting dapagliflozin, a recently approved drug. Researchers will observe how long patients stay on the medication, any side effects, and changes in symptoms and quality of life. The goal is to understand how t…

This study looks at how combat injuries impact the long-term health of U.S. service members, focusing on sleep problems, heart issues, and stress. About 200 participants will wear heart and sleep monitors and provide blood and urine samples. The goal is to understand connections …

This study looks at how a small change in the PDE3B gene affects the way the body handles fat and sugar. Researchers will compare two groups of people—those with the gene change and those without—to see differences in fat tissue function and overall metabolism. The goal is to und…

This study continues to follow over 4,000 women who were first enrolled during their pregnancy. Researchers want to learn how problems during pregnancy, like high blood pressure or diabetes, may be linked to heart disease later in life. Participants will complete surveys and may …

This study follows people who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring, cancer, or liver failure. About 121 adults will be monitored for up to 10 years with regular tests, scans, and questionnaires. The goal is …

This study looks at whether using large health databases and informational tools can help more people in high-risk communities take cholesterol-lowering statins to prevent heart attacks and strokes. Researchers will track over 500,000 people in Ontario communities with higher-tha…

This study looks at how daily experiences like stress and racial discrimination affect heart health in Black women aged 18-49. Researchers will monitor physical activity, sleep, and blood vessel function using wearable devices and lab tests. The goal is to understand what factors…

This study follows 10,000 Italian adults with COPD to understand how the disease affects their daily lives, including flare-ups, other health problems like heart disease, and risk of death. Researchers will collect information from medical records and routine check-ups over time.…

This study follows 347 heart surgery patients to find out why some develop swallowing problems. Researchers will identify risk factors and create simple bedside tests to catch these issues early. The goal is to improve care and prevent complications after cardiac surgery.

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers measured known risks like high blood pressure and diabetes to see how they affect older people's health over time. The goal was to …

This study follows 200 men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy) for at least 6 months. Researchers want to understand how this treatment affects the heart, including changes in heart function and the risk of heart failure. They wil…

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study looks at 100 adults with sleep bruxism (teeth grinding during sleep) to understand how it relates to sleep quality, heart health, thyroid function, and mental well-being. Participants will undergo sleep monitoring and fill out questionnaires. No treatment is given; the…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…

This study looks at whether a telehealth system can help rural patients with heart problems get better care. It connects local emergency teams and clinics with heart specialists at a larger medical center. About 215 adults with heart symptoms will take part. The goal is to see if…

This study looks at whether people with POTS (a condition causing a rapid heart rate upon standing) have higher levels of certain immune proteins that might attack their own nervous system. Researchers will measure these proteins in blood samples from 58 participants, including b…

This study reviews over 2,500 medical records to understand why some people with treated and controlled high blood pressure still die from heart attacks, strokes, kidney failure, or sudden death. It aims to find overlooked factors beyond blood pressure numbers that may lead to fa…

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …

This study was planned to see if giving nitric oxide during heart surgery helps protect blood vessels in patients whose vessels were already not working well. It was an add-on to a larger trial, but was withdrawn before any patients were enrolled. The goal was to measure blood fl…

This study aims to see if a high-sensitivity troponin blood test can better identify people at risk for heart disease during routine health checkups. Researchers will enroll up to 300,000 adults in India and classify them as low, moderate, or high risk based on the test results. …

This study looks at how two specific genes, SWAP70 and GMPR, may influence the risk of heart disease. Researchers will analyze blood samples from 100 healthy volunteers who have already had their genes mapped. The goal is to better understand the biological processes behind heart…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass surgery plus medications) versus medications alone. The goal is to see which strategy leads to fewer…

This study looks at how being in the intensive care unit (ICU) after heart surgery disrupts patients' natural sleep-wake cycles. Researchers will track sleep patterns and thinking skills in 15 adults who own an Apple smartphone. The goal is to understand how hospital routines aff…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk than others. Researchers will test a community-based behavior change program in 800 high-risk participants to see if it works better than usual care. The…

This study is testing a new imaging tool that combines two types of light to look inside heart arteries. Researchers want to see if this tool can predict which plaques will grow over time. About 40 adults with heart disease will be imaged at the start and again after one year usi…

This study looks at better ways to detect heart damage in adult cancer survivors who received certain chemotherapy drugs. Researchers are testing if an AI-powered ECG and a simple blood test can find early signs of heart trouble. The goal is to gather information needed to create…

This study was designed to see if a drug called abatacept could improve blood vessel function in older adults by targeting immune cells called T cells. It planned to enroll people aged 55-75 without major health problems. However, the study was withdrawn before any volunteers wer…

This study aims to better understand how blood pressure changes in the six weeks after childbirth. Researchers will give 300 new mothers a medical-grade smartwatch to continuously monitor their blood pressure. The goal is to learn how to predict and prevent serious complications …

This study follows 200 women with breast cancer who are receiving chemotherapy drugs doxorubicin or trastuzumab. Researchers want to understand how these treatments affect the heart over time and how factors like race, income, and access to healthcare play a role. Participants wi…

This study looks at what causes dangerous blood clots in the legs (venous thrombosis) and lungs (pulmonary embolism) by following over 21,000 African American and white adults from two large health studies. Researchers are tracking participants over time to find patterns and risk…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study is a first step toward creating a heart disease risk score designed specifically for women. Researchers will follow 176 women aged 25-55 who have had conditions like pre-eclampsia, gestational diabetes, or early menopause, which can raise heart risk. The goal is to bet…

This study is testing a program called CONNECT that helps more women and Black and Latino adults learn about and join heart health research. About 1,000 people with heart disease or risk factors like high blood pressure or diabetes will receive text messages with heart health inf…

This study was designed to see if giving nitric oxide gas during heart surgery changes levels of certain molecules linked to oxidative stress. It was an add-on to a larger trial and planned to include adults having elective heart surgery. However, the study was withdrawn before e…

This study looks at whether training peer coaches can help patients with limited health literacy talk to their doctors about preventing heart disease. About 60 adults at risk for heart disease will work with a peer coach before a doctor visit. The goal is to see if this approach …

This study tests whether a 30-minute educational website helps people who stopped taking statins due to muscle symptoms make informed decisions about restarting the medication. About 816 participants will either use the website or receive usual care. Researchers will track how ma…

This study is creating a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genes and other markers to better predict who is at risk for serious complications like kidney failure, heart disease, and stroke…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before e…

This study looks at different ways to share genetic research results with people who joined a biobank. Researchers want to see if using a website or chatbot is as good as talking to a genetic counselor by phone or video. About 2,500 adults with certain genetic changes will take p…

This study looks at how well a specific heart stent (SYNERGY) works in everyday medical practice in China. About 2,000 people with heart disease who receive this stent will be followed to see how they do. The goal is to gather real-world information, not to test a new treatment.

This study looks at how the timing of meals impacts the body's ability to use energy (metabolism) and insulin sensitivity in overweight adults aged 30 to 75. Researchers will track 200 participants to see if eating at certain times of day affects risk for type 2 diabetes and hear…

This study was designed to see if using a special pad along with a standard closure device could speed up artery sealing and reduce bed rest after a heart catheterization. It planned to enroll adults undergoing the procedure through the leg artery. However, the study was withdraw…

This study checks how often hospital staff have high levels of a type of cholesterol called Lp(a), which can raise the risk of heart disease. About 2,800 healthcare workers and their family members will give blood samples. The goal is to see how common this condition is in differ…

This study was designed to learn more about using a heart scan (coronary artery calcium score) to find hidden heart disease in people with diabetes. It planned to enroll adults with type 1 or type 2 diabetes who had no heart symptoms. The study was withdrawn before any participan…

This study collects blood samples and medical information from nearly 10,000 people undergoing heart tests at Cleveland Clinic and other hospitals. The goal is to create a large gene bank that researchers can use to better understand what causes coronary artery disease. Participa…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years. Researchers collect blood for genetic testing and perform heart MRI scans to look for scarring. The goal is to find better ways to diagnose the disease and understand how g…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, not individual patients. The goal is to see which strategies work best to get women to sign …

This study looks at heart MRI scans from 10,000 patients to learn how these images can help predict future heart problems. Researchers will track patients over time to see who develops heart disease or dies from it. The goal is to improve how doctors use MRI scans to diagnose and…

This study looks at whether a mobile app called PulsePoint can increase the number of people who receive CPR or a defibrillator from bystanders before emergency services arrive. About 340 adults who suffer a cardiac arrest in a public place will be included. Half of the emergency…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…