CARDIOVASCULAR DISEASES

This large study is testing whether aiming for a lower blood pressure target can better protect people with diabetes from serious heart problems and memory decline. It involves nearly 9,500 participants who have type 2 diabetes and are at high risk for heart disease. Participants…

This study is testing whether having extra appointments with a heart specialist at your local doctor's office leads to better management of health risks like high blood pressure and cholesterol. It compares this approach to standard care from a general practitioner. The goal is t…

This study is testing whether regularly eating dark chocolate can improve key markers of heart health. Researchers are comparing the effects of dark chocolate and white chocolate on blood pressure, cholesterol, and blood flow in 45 healthy adults. The goal is to see if dark choco…

This study is testing a medical device procedure called renal denervation for people whose high blood pressure remains uncontrolled despite medications. The procedure uses a catheter to deliver energy to nerves around the kidney arteries, aiming to lower blood pressure long-term.…

This study follows 5,391 people with stable heart disease for up to 10 years to see which initial treatment approach helps people live longer. Participants were originally assigned to either receive heart procedures plus medications or medications alone. Researchers are now track…

This study continues testing ralinepag, an experimental medication for pulmonary arterial hypertension (PAH), to understand its long-term safety and effectiveness. It enrolls 1,000 participants who have already taken ralinepag in previous studies and are already on standard PAH m…

This study is testing a new device called the Millipede Ring for people with a leaky mitral heart valve. The device is placed using a catheter through a vein, avoiding open-heart surgery. The goal is to see if this procedure is safe and works for patients who are too sick for tra…

This study is testing if a 30-minute educational website can help people who stopped taking their cholesterol-lowering statin pills due to muscle aches. Researchers want to see if using the website makes people more likely to try the medication again with their doctor and stick w…

This study is testing whether training 'peer coaches' can help patients with limited health literacy have better conversations with their doctors about reducing their risk of heart disease. The study involves 60 patients at a single clinic who are at risk for heart problems. Half…

This trial is testing a new device called the Edwards EVOQUE system, which is implanted via a catheter to replace a leaky tricuspid heart valve. It aims to see if this implant, along with standard medication, is safer and more effective than medication alone for patients with sev…

This study is testing if using a small, implanted heart monitor helps doctors better manage irregular heartbeats (atrial fibrillation or AFib) after a common procedure called catheter ablation. The monitor sends data to doctors, allowing for quicker treatment adjustments. The goa…

This study is testing whether colchicine, an anti-inflammatory medication, can slow the progression of aortic valve stenosis—a serious heart condition where the main heart valve narrows. Researchers are enrolling 150 patients with moderate but symptom-free valve narrowing to see …

This study is testing whether a one-year course of a dietary supplement called spermidine can help older adults with heart disease. Spermidine is a natural compound found in foods like whole grains and nuts. Researchers will check if it improves heart function, muscle mass, physi…

This study aimed to test a specialized catheter designed to deliver clot-dissolving medication directly to blood clots in the lungs. It planned to enroll up to 10 adults with serious but not massive lung clots. The trial was withdrawn by the sponsor before any patients were enrol…

This study is testing a new clinic program called ActivityChoice, designed to help cancer survivors start and maintain physical activity. The goal is to lower their risk of heart disease, which is a leading cause of death for survivors. The program uses simple stories and tools t…

This study compares two similar drug-coated stents used to prop open blocked heart arteries. It will enroll 550 patients in China who need this procedure to see if the newer Resolute Onyx stent performs as well as the established Resolute Integrity stent. Researchers will track p…

This study is monitoring how well SYNERGY heart stents work in real-world medical practice in China. It will follow 2,000 adult patients who receive these stents for heart artery blockages for up to 5 years. The goal is to collect safety and effectiveness data after the stents we…

This study is comparing two different types of biodegradable heart stents (SUPRAFLEX Cruz vs. SYNERGY) in patients with severe blockages in all three major heart arteries. About 1,550 participants will have the stents placed and be followed for at least a year to see which stent …

This study is testing a new device called the EVOQUE system, which is designed to replace a leaky tricuspid heart valve using a catheter inserted through a blood vessel, avoiding open-heart surgery. The trial aims to see if this procedure is safe and effective at reducing severe …

This study is testing a new medical device called the Aventus Thrombectomy System. It is designed to physically remove dangerous blood clots from the lungs of patients with a sudden, severe pulmonary embolism. The trial will enroll 130 adults to see if the procedure is safe and e…

This study is testing if adding a low dose of colchicine, an existing anti-inflammatory drug, to standard diabetes care can reduce inflammation and lower the risk of heart disease in adults with type 1 diabetes. About 100 participants, who have type 1 diabetes and signs of inflam…

This was an add-on study to a larger trial testing if breathing nitric oxide gas during and after heart surgery helps protect patients' blood vessels. It focused on patients with existing blood vessel problems who were having long surgeries using a heart-lung machine. The goal wa…

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This study is testing how well a heart health education program works when run by local community members. It involves about 210 Black adults living in rural eastern North Carolina who have risk factors for heart disease. The main goal is to see if the program helps lower partici…

This study is comparing the safety and effectiveness of Onyx brand heart stents against other drug-coated stents in real-world medical practice. It will follow 4,500 adults with blocked heart arteries who receive an Onyx stent. Researchers will track complications like blood clot…

This study is testing whether a 4-week mindfulness training program delivered through a smartphone app can help reduce stress and improve blood pressure in adults aged 45+ who are at risk for heart disease. About 105 participants were randomly assigned to either use the daily min…

This trial tested a new device called the Tendyne System, which is implanted via a small incision to fix a severely leaky mitral valve. It was for people with symptoms like shortness of breath who were considered too high-risk for traditional open-heart surgery. The study compare…

This study is testing whether connecting rural paramedics, emergency rooms, and clinics with heart specialists via video calls improves care for people with chest pain or trouble breathing. It involves about 215 adult patients in Wilkes County. The goal is to see if this teleheal…

This study is testing the safety and effectiveness of a specific drug-coated heart stent (the Medtronic Resolute Onyx) in Chinese patients with blocked coronary arteries. About 591 participants who are eligible for a standard artery-opening procedure (angioplasty) will receive th…

This study is testing whether proactive, culturally tailored outreach can help more Black, Indigenous, and People of Color (BIPOC) adults successfully quit smoking. Researchers are comparing standard care against an enhanced program that actively reaches out to connect 700 eligib…

This study is testing whether an inhaled drug called mosliciguat is safe and effective for people who have high blood pressure in their lungs (pulmonary hypertension) caused by underlying lung scarring (interstitial lung disease). About 135 participants will be randomly assigned …

This study aims to find better ways to check for heart damage in adults who have finished chemotherapy for cancer. Researchers are testing if a simple AI analysis of a heart tracing (ECG) or a blood test can reliably detect a weakened heart pump. The goal is to gather data to pla…

This study is testing whether a home blood pressure monitor with a built-in heart rhythm sensor can accurately detect atrial fibrillation (AFib), a common irregular heartbeat. Researchers are comparing the device's readings against standard hospital ECG machines in 160 adults. Th…

This study is testing a specific screening method to find undiagnosed heart failure in people with diabetes who are at high risk. About 700 participants are being randomly assigned to either receive this new screening or continue with their usual care. The screening involves a bl…

This study is exploring whether biomarkers found in fluid just beneath the skin can help doctors detect and monitor cardiovascular diseases earlier. Researchers are comparing this skin fluid to blood samples from two groups: older adults with heart failure and younger, healthy ad…

This study is testing a new method to find people at high risk for atrial fibrillation (AF), a common heart rhythm problem that can lead to stroke. It uses a computer-based risk score from health records to identify nearly 2,000 participants, who then receive remote heart monitor…

This Pennsylvania-based study aims to understand and reduce differences in heart disease risk among different groups. Researchers are following 2,000 adults to identify who is at highest risk. About 800 higher-risk participants will try a special education program focused on diet…

This VA study aims to improve how 20 VA medical centers provide virtual health programs to women Veterans. It's testing two different support strategies to help these facilities successfully offer proven programs for preventing heart disease, diabetes, and depression. The goal is…

This study is testing if using a detailed heart scan (CTCA) to guide treatment is better at preventing fatal heart attacks than the current standard method, which uses a general risk score. It involves over 6,000 middle-aged adults in Scotland who have risk factors for heart dise…

This study is testing whether personalized counseling sessions can help prevent high blood pressure in adults living in slums in Dhaka, Bangladesh. Researchers will work with 1,700 healthy adults who have not been diagnosed with hypertension, providing them with 20 short counseli…

This study aimed to compare two FDA-approved devices that help seal the artery after heart catheterization through the groin. Researchers wanted to see if using both devices together would help patients walk sooner after their procedure compared to using just one device. The tria…

This study is testing whether structured exercise programs can help older adults living with HIV in Côte d'Ivoire stay mobile and independent. It compares a group exercise class, a home-based program with phone support, and general health education. The goal is to see which appro…

This study aims to find out how common high levels of a blood fat called lipoprotein(a) are among hospital staff and their families. Researchers will measure this in about 2,800 people and then follow them over time to see if higher levels are linked to future heart problems. The…

This study aims to understand what causes dangerous blood clots in the lungs (pulmonary embolism) and legs (deep vein thrombosis). Researchers are following over 21,000 African American and white adults who were already part of two large heart health studies. They are collecting …

This study aims to better understand blood pressure changes in the 6 weeks after childbirth. Researchers will give 300 new mothers a special smartwatch that continuously monitors blood pressure to see how patterns differ between low-risk, medium-risk, and high-risk women. The goa…

This study aims to understand why and how certain breast cancer drugs can damage the heart over many years. Researchers will follow 200 women for up to 15 years, tracking their heart health with regular scans and surveys. The main goal is to learn how a person's background—includ…

This was an add-on study to a larger trial testing nitric oxide gas in heart surgery patients. It aimed to understand the biological mechanisms—specifically how nitric oxide affects oxidative stress levels in the blood—that might explain why the gas could help reduce post-surgery…

This study is testing whether a new genetic risk score helps doctors and patients manage heart disease risk better. It will follow 1,000 adults without known heart disease for 5 years to see if getting this score changes how doctors prescribe medications or order tests, and if it…

This study aims to understand why some patients develop swallowing problems after heart surgery. Researchers are following 347 patients to identify risk factors and create simple bedside screening tools. The goal is to improve care by predicting and catching these complications e…

This study tests whether sharing important genetic health risk information through a secure website is as effective as sharing it through a phone call with a genetic counselor. Researchers will enroll 2,500 people who previously donated samples to a biobank and have a genetic res…

This study aims to understand the long-term health of people who have been cured of chronic Hepatitis C. Researchers will follow 121 participants for up to 10 years to see if cured patients still develop liver complications, cancer, or other health problems. The goal is to learn …

This large study aims to see if a very sensitive blood test for heart muscle damage (hs-TnI) can better identify people at risk for future heart disease during routine health checkups. It will enroll 300,000 adults in India to create a risk model and track their health outcomes. …

This study aims to understand why some people with diabetes develop serious heart and kidney problems while others do not. Researchers are collecting detailed health information and blood samples from 48,000 people with diabetes in Hong Kong to look for genetic and other biologic…

This study aims to find out if some people with Postural Tachycardia Syndrome (POTS) have specific immune proteins that might cause their symptoms. Researchers will measure these proteins in the blood of 58 people with POTS and healthy volunteers to see if they are linked to the …

This study is testing whether a new imaging technique called OCT-NIRAF can help doctors better understand plaque buildup in heart arteries. Researchers will use this special imaging during heart procedures on 40 participants with heart disease, then check for plaque changes one y…

This research project is analyzing thousands of existing medical studies to understand a puzzling problem: why do some patients with high blood pressure who are on medication and have their blood pressure under control still die from heart attacks, strokes, or kidney failure? The…

This long-term study followed nearly 5,900 adults aged 65 and older to identify what factors predict heart disease and stroke in the elderly. Researchers tracked participants' health over decades, using exams and tests to understand how risk factors like high blood pressure and c…

This study is trying to learn if heart MRI scans and blood tests can predict who will develop serious heart problems or die over the next 10 years. Researchers are following 10,000 patients who are already getting heart MRIs for medical reasons. They'll collect scan data, blood s…

This study aims to understand how the intensive care unit (ICU) environment disrupts patients' natural sleep-wake cycles (circadian rhythms) after heart surgery. Researchers will monitor 15 adult patients' sleep patterns, cognitive function, and how often they're visited by staff…

This study aims to understand how a specific gene, PDE3B, affects how the body processes fats and sugars. Researchers will compare 40 people who have a version of this gene that may reduce its function to people with the typical version. By taking blood and small fat tissue sampl…

This study is investigating whether the time of day you eat most of your calories affects your body's metabolism, insulin sensitivity, and blood pressure. Researchers are enrolling 200 overweight adults without diabetes to test if shifting calories to morning, evening, or spreadi…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This study aims to see if eating walnuts causes changes in cholesterol levels, inflammation, and the bacteria in the gut. It involves about 30 overweight adults aged 45-70 with high LDL ('bad') cholesterol. Participants will follow specific diets with and without walnuts for seve…

This study aimed to understand if a specific type of immune cell (T cells) causes arteries to stiffen and function poorly as people age. Researchers planned to test this by giving an existing arthritis drug, Abatacept, to healthy older adults to see if it improved artery health. …

This study is testing a new online platform called CONNECT, designed to help more women, Black, and Latino adults join heart disease research. The program sends educational text messages about heart health and clinical trials for one year and helps connect interested people to on…

This study aimed to understand how doctors in France use a heart calcium scan to assess heart disease risk in people with diabetes. It planned to observe how test results influence decisions for further heart tests or treatments. The study was withdrawn before any participants we…

This study aims to understand why Black people living with HIV are at higher risk for serious health problems like kidney disease, diabetes, and heart disease. Researchers collected health information and genetic samples from over 3,000 Black participants with HIV across the UK. …

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aims to collect blood samples and health information from thousands of patients with heart conditions to create a large gene bank. Researchers will store DNA and medical data to help future studies identify genetic factors linked to coronary artery disease. The goal is…

This study aims to find out why people of South Asian descent have higher rates of heart disease and stroke, even when typical risk factors are accounted for. Researchers are following over 2,300 South Asian adults in the US for several years to identify new causes. The goal is t…

This study aims to understand the complex links between sleep bruxism (nighttime teeth grinding) and other health issues like sleep apnea, heart disease risk, thyroid problems, and stress. Researchers will observe 100 adults who grind their teeth during sleep, using sleep studies…

This study aims to understand how the drug dapagliflozin is used for heart failure in real-world medical settings in Germany. It will observe 765 patients who have recently started taking the drug to see how long they stay on it, if their symptoms and quality of life improve, and…

This study is observing thousands of University of North Carolina alumni over many years to learn if personality traits like hostility and depression are connected to the development of heart disease. It is not testing a treatment; instead, it aims to gather knowledge by tracking…

This study aims to understand how two specific genes (SWAP70 and GMPR) influence a person's risk of developing heart disease. Researchers will invite 100 healthy volunteers who have already had their genes analyzed to attend a single visit for blood tests and health measurements.…

This study follows thousands of women for years after their first pregnancy to understand how pregnancy complications might affect future heart health. Researchers collect health information, measurements, and blood samples to identify early signs of heart disease risk. The goal …

This study aimed to understand how powerful cholesterol-lowering drugs (PCSK9 inhibitors) affect inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation in participants already on standard statin medicat…