Could POTS be an autoimmune disorder? new study investigates

NCT ID NCT02725060

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study at Vanderbilt University Medical Center is looking at whether people with postural tachycardia syndrome (POTS) have higher levels of certain immune proteins that might affect their symptoms. Researchers will measure these proteins in blood samples and test how the heart and blood vessels respond to specific drugs. The goal is to understand the role of the immune system in POTS, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: phenylephrine, isoproterenol, and low-dose radiation
What this could lead to: If successful, this could help explain why some people develop POTS and point toward immune-based treatments.
What could go wrong: This is an early observational study with only 58 participants, so results may not apply to everyone with POTS. It is not testing a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac autonomic nervous system disorder cardiac rhythm disease cardiovascular disorder Orthostatic Intolerance postural orthostatic tachycardia syndrome primary dysautonomia Tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRHYTHMIAS, CARDIAC AUTONOMIC NERVOUS SYSTEM DISEASES CARDIOVASCULAR DISEASES ORTHOSTATIC INTOLERANCE POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME POSTURAL TACHYCARDIA SYNDROME PRIMARY DYSAUTONOMIAS TACHYCARDIA

Contacts and locations

Locations

Autonomic Dysfunction Center

Nashville, Tennessee, 37232, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73117-1213, United States

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