CARDIOVASCULAR DISEASES

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This study tests a program designed to help men with prostate cancer manage their heart health while undergoing hormone therapy (ADT). The program involves two counseling sessions with a nurse or physician assistant to educate about cardiovascular risks and how to reduce them. Re…

This study tests a device that uses radiofrequency energy to disrupt nerve signals in the kidney and liver arteries, aiming to lower blood pressure in people with uncontrolled hypertension. About 175 adults aged 18-80 with high blood pressure despite medication will be enrolled. …

This study tests a decision aid—a tool that provides information and goal-setting exercises—to help women who had high blood pressure during pregnancy take steps to protect their heart health after childbirth. The goal is to improve engagement in preventive care like blood pressu…

This study is a registry that follows about 960 people with coronary artery disease who are treated with a special balloon coated with a drug called sirolimus. The balloon is used to open blocked heart arteries. Researchers will track heart-related events like death, heart attack…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study tests whether regular phone calls and text messages with lifestyle advice can help adults in Nepal with uncontrolled high blood pressure lower their numbers. Five hundred participants will receive either the mobile health program or usual care for six months. The goal …

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests a smartphone program called HeartSteps to help people with heart disease stay physically active after cardiac rehab. Sixty adults will wear a Fitbit and use the app for 3 months to see if it boosts their weekly exercise minutes. The goal is to learn how to best s…

This study compares two different drugs, vicadrostat and spironolactone, both taken with empagliflozin, to see how they affect kidney function and protein levels in blood and urine. The trial involves 100 adults with chronic kidney disease and heart disease or heart failure. Part…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study compares two approaches for low-risk patients with small blood clots in the lungs (isolated subsegmental pulmonary embolism). Half will receive standard blood-thinning medication (rivaroxaban), while the other half will get a placebo and be closely monitored. The goal …

This study is testing whether nattokinase, an enzyme from fermented soy, can reduce inflammation and improve cholesterol levels in people with high cholesterol. Researchers will measure blood markers of inflammation and heart risk in 48 adults over two months. The goal is to see …

This study is testing whether taking green propolis extract and royal jelly together can reduce inflammation and oxidative stress in people with high blood pressure or chronic kidney disease. Over two months, 153 participants will take capsules of the supplements or a placebo. Re…

This early study tests a device called the A-FLUX Reducer, which is implanted into a vein in the heart to help blood flow. It is for people with chest pain caused by problems in the heart's tiny blood vessels (microvascular dysfunction). The study will enroll 30 adults and focus …

This study tests whether drinking traditional kefir every day for 12 weeks can improve blood sugar control and heart health in 156 adults who are overweight and either at risk for or already have type 2 diabetes. Participants will drink either kefir or plain milk. The main goal i…

This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood p…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by lung scarring. The goal is to see if the combination is safe and tolerable. About 20 adults with this condition will particip…

This study tracks 1,000 Medicare patients with uncontrolled high blood pressure to see if a procedure called renal denervation (using the Symplicity Spyral device) helps lower blood pressure and prevent heart attacks or strokes over two years. Researchers will compare patients wh…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This early study is testing a new device called the TRiCares Topaz, which is threaded through a vein to replace the tricuspid valve in the heart. It is for adults with severe tricuspid valve leakage who are not good candidates for open-heart surgery. The study will check if the d…

This study is testing a new device called the TRiCares Topaz system to replace a leaky heart valve (tricuspid valve) without open-heart surgery. It will enroll 80 adults with severe leakage who are at high risk for traditional surgery. The goal is to see if the device is safe and…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, reducing blood backflow. The goal is to see if it improves symptoms, walking ability, and …

This study is testing whether adding registered dietitian counseling or occupational therapy home safety tips to regular home-delivered meals can reduce fall risk in older adults. Researchers will compare four groups: meals alone, meals plus dietitian, meals plus occupational the…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This study tests whether getting a flu vaccine soon after a heart attack can reduce inflammation in the heart's arteries. Researchers will compare the vaccine to a placebo in 90 adults who recently had a heart attack and a stent procedure. They will use special CT scans and blood…

This study looks at whether a dual bronchodilator (a combination inhaler) can improve breathing, heart function, and quality of life in people newly diagnosed with moderate-to-severe COPD. Researchers will measure changes in exercise capacity and lung function over 12 weeks. The …

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

This large phase 3 trial is testing whether colchicine (a gout medication) and low-dose aspirin, taken together or alone, can prevent heart attacks, strokes, and cardiac death in 10,000 high-risk people with type 2 diabetes who have not yet had a heart-related event. Participants…

This study tests whether adding organizational support to a church-based exercise program helps Latinas become more active. 560 Latina women from 28 churches will be assigned to one of three groups: standard exercise classes, enhanced with leader training and tailored messaging, …

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study compares the effects of healthy diets containing cottonseed oil versus other common plant oils on heart health markers like cholesterol. Researchers will enroll 52 adults with elevated LDL cholesterol and overweight. Participants will follow each diet for 4 weeks in a …

This study tests if using focused ultrasound to modify fat around the kidney can safely lower blood pressure in people with hypertension. About 30 adults with mild high blood pressure despite medication will be enrolled. The treatment is compared to a sham procedure to see if it …

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study looks at how well a device that uses ultrasound to calm kidney nerves can lower blood pressure in people 65 and older whose blood pressure is not well controlled. Researchers will track 1,000 patients over time using electronic health records. The goal is to see if thi…

This study is testing whether whole milk or nonfat milk is better for body composition and health in 200 children aged 9-12 who have a higher BMI. Families receive weekly milk deliveries and monthly check-ins. The goal is to see which milk type helps reduce fat mass and improve m…

This study tests a 24-week community-based lifestyle program called Inspire HER for Black women aged 30-79 with heart, kidney, or metabolic conditions. The program provides health education, physical activity, and social support to improve heart health. Researchers will also comp…

This study is tracking 2,000 people with coronary artery disease who receive either a Synergy XD or Synergy Megatron stent during a routine procedure to open blocked heart arteries. Researchers want to see how these stents perform in everyday medical practice compared to other dr…

This registry tracks 160 high-risk patients with resistant hypertension due to narrowed kidney arteries. All patients undergo a procedure called percutaneous transluminal renal angioplasty (balloon dilation, often with a stent) to open the blockage. Researchers will measure chang…

This study tests whether omega-3 supplements can reduce inflammation and improve heart health differently depending on a person's genetic makeup and ancestry. Two hundred healthy adults of African or European descent will take omega-3s or a placebo for 12 weeks each, then switch.…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests whether adding stair climbing to a brisk walking routine lowers blood pressure more than walking alone. 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk walking onl…

This study tests a new device called the SoniCracker IVL, which uses tiny shockwaves to break up hard calcium deposits in heart arteries. The goal is to make it easier to place stents and improve blood flow. About 40 adults with calcified coronary arteries will be enrolled. Resea…

This study tests whether a digital heart health program (a web app, online classes, and special foods) added to usual care can lower cholesterol and reduce heart attacks in people with heart disease or risk factors. About 1,100 participants will be randomly assigned to the progra…

This study tests several affordable oral medications—including semaglutide, empagliflozin, metformin, and pioglitazone—to see if they can reverse prediabetes, promote weight loss, and lower heart disease risk in Hispanic adults. Researchers will monitor blood sugar, body fat, and…

This study tests whether delivering healthy DASH-diet groceries and dietitian support to people with high blood pressure in Florida, Georgia, and Tennessee can lower their blood pressure. About 150 adults with elevated blood pressure will receive all their groceries for 4 weeks. …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This early-phase study tests whether empagliflozin, a drug originally for diabetes, can improve left atrial function in 80 adults over 60 with hypertension and obesity who are at risk for heart failure. Participants take either a 10 mg empagliflozin tablet or a placebo daily for …

This study tests whether adding a structured self-management program (DECIDE) to standard community health worker support helps 500 Philadelphia residents aged 35-75 better manage heart disease risks and meet their social needs. Participants will either receive the enhanced progr…

This study is tracking 2,000 heart disease patients who receive the VIVO ISAR stent, a drug-coated device that releases medication to keep arteries open. Participants will take blood thinners for three months or less after the procedure. Researchers are monitoring for heart attac…

This study tests whether a 3-month cooking class focused on the Mediterranean diet can improve heart health and blood sugar in racially diverse seniors aged 55 and older. Participants will learn to cook healthy meals in a community kitchen, while researchers measure changes in bl…

This study tests a school program called Strong Teens for Healthy Schools (STHS) that teaches middle school students about civic engagement, healthy eating, and physical activity. The goal is to help students improve their own health and make positive changes in their school envi…

This trial tests a special balloon coated with sirolimus (a drug) to treat small arteries in the heart, compared to standard drug-eluting stents. About 1605 people with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see if the ballo…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…

This study tests whether artificial intelligence can plan cardiac MRI scans as accurately as expert radiographers. 150 adults will receive both an AI-planned and a standard scan, and doctors will compare the image quality and time taken. If successful, AI could help reduce long w…

This study tests a new, non-invasive device called the Cardiac Performance System (CPS) that uses sensors on the skin to measure heart function. Researchers will compare its readings to those from standard invasive right heart catheterization in 1000 adults. If accurate, the CPS …

This study is testing a new smartphone-connected 12-lead ECG device to see if it can accurately diagnose heart attacks (STEMI and NSTEMI) in people with chest pain. Researchers will compare the smartphone ECG readings to standard hospital ECGs in 1000 adults. The goal is to valid…

This study tests a new radioactive dye called 68Ga-NI-FAPI for PET/CT scans. It aims to better detect diseases like tumors, heart problems, and lung scarring by targeting a protein linked to tissue damage. About 30 people, including healthy volunteers and patients, will take part…

This study at Mayo Clinic is testing whether voice recordings can help detect pulmonary hypertension, a serious condition affecting the heart and lungs. Researchers will collect voice samples from 7,000 people already scheduled for an echocardiogram. The goal is to see if voice p…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study is testing whether taking daily aspirin (100 mg) along with a high-intensity statin can prevent heart attacks, strokes, and other serious cardiovascular events in people aged 40–75 who have severe coronary artery calcification (calcium score ≥300). About 5,000 particip…

This study tests a digital lifestyle program for adults aged 40-60 in Swedish primary care. Participants receive standard health advice plus app-based support for diet, exercise, alcohol, and smoking. The goal is to see if the program improves cholesterol and other heart health m…

This large study is testing whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and death. Participants are randomly assigned to take either the drug or a placebo for several years. The goal is to see if this simple pill ca…

This study tests a program called Mom♥Health to help mothers of young children reduce their risk of heart disease. About 40 moms with kids aged 5 or younger will receive support and resources through their child's daycare center. The goal is to see if this approach is practical a…

This study tests whether telling people their genetic risk for heart disease, along with personalized coaching, helps them adopt healthier habits. About 650 hospital staff members aged 40 and older will get their genetic risk score and meet with a cardiologist for tailored advice…

This study looks at a program called Healthy School Recognized Campus, which helps schools in Texas offer more physical activity and nutrition programs to students. About 900 kids in grades 4 through 9 will take part. Researchers want to see if the program improves kids' health, …

This study is testing whether eating a soft chew containing plant stanols every day can reduce asthma symptoms in people with allergic asthma. Plant stanols are known to lower cholesterol, but they may also shift the immune system away from the type of response that triggers asth…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study looks at whether adding a special whey protein supplement to a high-fat meal can improve markers of heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will each try the supplement and a placebo on sep…

This study tests whether adding a specific nerve block (PIFB) to standard pain management helps patients recover faster after open-heart surgery. It compares two types of nerve blocks in 123 adults undergoing elective heart surgery. The goal is to see if one block is at least as …

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether adding extra support—like booster sessions and a website—to an 8-week telephone mindfulness program can better reduce stress, anxiety, and depression in people with heart disease or risk factors. Researchers will compare different program options in 160 a…

This study tests whether a non-medication sleep program (CBT-I) can improve sleep, PTSD symptoms, and heart health in older adults with PTSD who still have sleep problems after PTSD therapy. About 167 veterans aged 50 and older will receive PTSD therapy first, then the sleep prog…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study looks at two different virtual exercise programs for women with coronary heart disease. Over 12 weeks, participants will exercise twice a week either with high-intensity intervals or moderate continuous activity. The goal is to see which type better improves exercise c…

This international study tests whether a smartphone game called Heart Farming can help inactive heart failure patients sit less and move more. 750 participants will either get standard activity advice or the game, which rewards walking with virtual farm products. The goal is to s…

This study tests whether easy home-based strategies—like wearing blue-light blocking glasses, standing for 10 minutes each hour, and not eating after 8pm—can reduce the negative health effects of evening screen time. Researchers will track 30 adults with obesity or prediabetes wh…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether giving iron infusions after a minimally invasive heart valve replacement (TAVI) helps patients with aortic stenosis and iron deficiency feel better and walk farther. About 402 older adults will be randomly assigned to receive iron or standard care. Resear…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests a new type of mirror therapy to help people who have had a stroke regain movement in their arm and hand. The therapy uses a mirror to show the unaffected arm moving, which tricks the brain into thinking the affected arm is moving too. 81 participants will receive…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for people with heart failure. Participants use the app for education, mindfulness, and physical activity guidance, plus periodic video calls with an exercise physiologist. The goal…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study follows 650 adults who had pneumonia (including COVID-19) to see how the infection might lead to heart disease later. Researchers will collect blood samples, run heart and lung tests, and track heart attacks, strokes, and other events over three years. No new treatment…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This registry is an observational study that will follow 5,000 people who receive a Medtronic heart surgery device. Its goal is to confirm the devices are safe and work well in everyday use, and to spot any new risks. No new treatment is being tested—just real-world monitoring.

This study looks at how people with ME/CFS (chronic fatigue syndrome) and people with heart conditions feel after a bike exercise test. Researchers want to see if the type and timing of symptoms after exercise are different between the two groups. 80 adults will take part, and th…

This study follows 1600 breast cancer patients for up to 15 years to see if modern, lower-dose radiotherapy causes fewer heart problems than older methods. Researchers will use heart scans, blood tests, and ECGs to detect early signs of damage. The goal is to compare heart diseas…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study looks at whether giving patients who come to the emergency department with chest pain a simple explanation of their heart disease risk can help them understand and improve their health. Researchers will talk with 118 adults in Scotland who have slightly elevated tropon…

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study looks at 500 adult survivors of childhood cancer to see if a newer type of heart ultrasound, called speckle tracking, can find heart problems earlier than the usual method. Researchers want to know if this technique can detect heart damage sooner, which could help with…

This study follows 500 American Indian adults with early kidney disease to learn how their condition progresses and what factors affect heart health. Researchers will measure kidney function and track heart events like heart attacks and strokes. The goal is to fill knowledge gaps…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This study looks at 2,000 adults aged 50+ to see if certain blood cell mutations are tied to aging and heart disease, beyond just getting older. Researchers will compare blood and mouth cells to find mutations and track health over time. The goal is to understand these mutations'…

This study is a worldwide registry that follows 5,000 adults with breast cancer, blood cancers, or those on immune checkpoint inhibitors. Researchers collect medical records, lab results, and imaging to identify who is at risk for heart problems during or after cancer treatment. …

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed deep in the brain for less than 30 days to deliver mild electr…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is testing a new way to understand how nerves in the kidney affect blood pressure. About 19 adults with high blood pressure will receive mild electrical stimulation to kidney nerves before and after a procedure that quiets those nerves. The goal is to learn how the bod…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study looks at whether a lower daily dose of aspirin (50 mg) is as effective and safer than the standard dose (100 mg) for preventing heart attacks and strokes in Chinese patients aged 60 and older with heart disease. Researchers will follow over 5,400 participants for up to…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study will see if an artificial intelligence (AI) model can predict major heart problems within 30 days after gastrointestinal surgery better than current risk scores. Researchers will review medical records of 5,000 adults having surgery at Bach Mai Hospital in 2025-2026. T…

This study looks at how a heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will test 200 adults with different genetic versions of ANP to see how their bodies respond to exercise and sugar. The goal is to understand why some p…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study follows 300 preterm and full-term infants from birth to age 10 to see how their kidneys grow and function. Researchers use ultrasound and blood/urine tests to find early markers of kidney injury and high blood pressure. The goal is to identify at-risk children before t…

This study is testing whether a special wearable device, combined with artificial intelligence, can help people with chronic heart failure avoid hospital visits. About 205 adults will wear the device for six months while their health data is monitored remotely. The goal is to see…

This study looks at why people with hemophilia (a bleeding disorder) are less likely to die from heart disease. Researchers will use a new, detailed CT scanner to compare heart artery health in 80 men aged 45+ with hemophilia to similar men without it. The goal is to understand h…

This study looks at whether remote exercise programs (using a smartphone app, live video classes, or in-person sessions) can help people at risk for heart disease become more active. About 30 adults over age 45 who are not currently meeting exercise guidelines will take part. The…

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their family members to compare DNA. The goal is to identify gene c…

This study aims to describe how a genetic heart condition called PKP2-ACM naturally progresses over time in people who receive standard care. Researchers will monitor heart rhythm, biomarkers, and quality of life in 36 participants aged 12 and older. The goal is to better underst…

This study looks at how the bacteria living in your gut (the microbiome) are linked to health and diseases like cancer and heart disease. Researchers will collect information from 16,000 adults over age 40 through questionnaires and samples. The goal is to build a large database …

This study aims to improve how doctors interpret stress echocardiograms—ultrasounds of the heart during exercise—by using machine learning. Researchers will analyze data from 1,250 patients to develop more accurate tools for detecting blocked arteries and heart attack risk. The g…

This University of California, Davis study is testing whether chocolate made from chardonnay grape leftovers (called marc) can improve blood vessel function and reduce oxidative stress. Five adults with higher body weight and slightly reduced blood vessel flexibility will eat dif…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have a 'non-dipping' pattern where blood pressure stays high at night. The goal is to uncover mec…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study is testing whether a special CT scan of the heart (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. About 332 patients on the transplant list will get a single CTCA scan before their surgery. Researchers will th…

This study looks at whether adding green spaces, like trees and parks, to neighborhoods can improve heart health and overall well-being. Researchers will follow 835 adults aged 30-70 living in Louisville, measuring things like artery stiffness, blood pressure, and body compositio…

This study looks at how small genetic changes influence molecules that naturally resolve inflammation. Researchers will analyze blood samples from 200 volunteers of Bangladeshi and Pakistani origin to understand why some people develop chronic inflammatory diseases like arthritis…

This study is building a large group of 600 people with immune-mediated inflammatory diseases (like arthritis or lupus) to track their heart health over time. Researchers will use simple blood tests to see if certain heart-related markers can predict future heart problems. The go…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study looks at whether simple, non-invasive skin tests can detect early signs of heart disease by measuring how well small blood vessels work. Researchers will study 900 people aged 60-75, comparing skin blood flow measurements with detailed heart scans. The goal is to find …

This study is testing whether a CT scan can do the same job as an MRI for looking at heart muscle damage and scarring. MRI is the current gold standard but is slow, expensive, and not suitable for everyone (e.g., people with pacemakers or claustrophobia). The researchers will enr…

This study is creating a huge collection of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain disorders. Part…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study is looking at how lifestyle choices like diet, exercise, stress, and sleep relate to heart health measures such as blood pressure and cholesterol. Researchers will ask 100 adults and young people to fill out a questionnaire about their habits. The goal is to better und…

This study looks at how genetic factors influence the risk of liver damage and heart problems in people with fatty liver disease. Researchers will enroll 2,500 blood donors aged 40-65 who are overweight or have related conditions like high blood sugar or high cholesterol. The goa…

This study will assess the diet, heart health, body composition, mental wellbeing, and physical performance of 600 U.S. Army soldiers. Researchers aim to gather detailed data on nutrition and health, similar to a national survey but tailored for the military. The goal is to bette…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study follows 300 people who are having weight-loss (metabolic) surgery to see how their gut bacteria change over time and how those changes relate to heart health, diabetes, and cholesterol. Participants provide blood and stool samples before surgery and at several follow-u…

This study tests a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for healthy …

This study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health problems, such as heart disease and thinking issues, that survivors face. By an…

This study looks at how brief mental stress affects heart function and brain health in 450 adults aged 40-60. Participants complete two sessions: one with stress tests and heart monitoring, another with brain scans and memory tests. The goal is to understand links between stress …

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…

This study examines whether community park-based fitness programs can improve cardiovascular health in adults aged 50 and older. Researchers will analyze data from 1,000 participants who took part in exercise sessions including aerobics, strength training, and balance exercises. …

This study will collect DNA samples and medical records from 1,000 people with panvascular disease, a condition where arteries in multiple parts of the body are narrowed or blocked. Researchers will analyze this data to better understand what causes the disease and how it progres…