CARDIOVASCULAR DISEASES

This study compares two cholesterol-lowering approaches in about 1,950 adults with chronic kidney disease and heart disease. One group gets a moderate statin plus ezetimibe, the other a high-dose statin alone. The goal is to see if the combination is as good at preventing heart a…

This study tests a new biodegradable device to close a patent foramen ovale (PFO), a small hole in the heart that can cause strokes. About 258 people aged 18-65 who have had a stroke or TIA linked to a PFO will receive the device. The goal is to see if it safely and effectively s…

This study tests if dapagliflozin, a drug used for diabetes, can improve exercise ability and heart function in people who had the Fontan procedure (a surgery for a single-ventricle heart defect). About 30 adolescents and adults will take the drug daily for 3 months. The main goa…

This study tests whether adding Vitamin C, Omega-3 fatty acids, and other supplements to standard care can improve recovery in 108 adults after coronary artery bypass surgery. Participants will take the supplements daily for 10 weeks starting 15 days after surgery. The goal is to…

This study will follow about 2,700 women aged 45-75 who are going through menopause and have a higher risk of heart disease. Researchers want to see if newer hormone replacement therapies (like creams, gels, or sprays) can lower the chance of heart attacks, strokes, or other hear…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed to open blocked arteries in people with coronary artery disease. About 1,859 participants will receive either the dissolving stent or a standard permanent stent. The goa…

This study tests Mobili®, a portable digital dispenser that gives the right pills at the right time, to help people with multiple chronic diseases stick to their medication schedule. About 96 adults with diabetes or heart disease who take at least two daily oral medications will …

This study tests whether vericiguat, a drug that boosts a natural signaling molecule called cGMP, can improve how the body uses energy and responds to insulin. It involves 200 Black adults with obesity and insulin resistance. Over 12 weeks, participants will receive either verici…

This study looks at whether a supplement called propionic acid can improve blood vessel function in 20 people with coronary artery disease. Researchers will measure changes in artery health and inflammation over 4 weeks. The goal is to see if this gut-related compound can help ma…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs of people with heart failure. The treatment aims to reduce serious heart events like hospitalizations or death. About 750 adults with stable heart failure will be randomly assigned…

This study looks at whether showing women detailed images of their own artery plaque can motivate them to make healthier choices and stick with preventive treatments. The goal is to lower the chance of developing high blood pressure one year after giving birth. The trial includes…

This study will test if a mobile app called m-LIfE can help office workers in Pakistan sit less, move more, and eat healthier to prevent heart disease. About 84 bank employees will either use the app for 12 weeks or get basic health pamphlets. Researchers will check if the app is…

This study tests whether a special indoor air cleaner can reduce heart disease risk in adults aged 55 to 79 living in Montana, where wildfires often worsen air quality. Participants will use the air cleaner at home, and researchers will measure changes in heart health scores, blo…

This study looks at whether a daily supplement called Neurofast® can help people who have both anxiety and heart problems. About 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, depression, heart rate, …

This study aims to find better ways to deliver health services to women Veterans, especially those in midlife. Researchers will test two different strategies at 18 VA sites to see which one helps more women get the care they need. The study focuses on improving engagement with pr…

This study observes 30 adults with dilated cardiomyopathy (a weakened heart muscle) caused by changes in the BAG3 gene. Researchers will track heart function, symptoms, and health outcomes over time to better understand how the disease progresses. No treatment is given—the goal i…

This study tests whether using a non-invasive electrocardiographic monitor can allow patients with heart rhythm problems after TAVI valve replacement to be discharged early safely. About 100 adults who had a successful TAVI and have certain conduction disorders will be monitored.…

This study looks at whether the cancer drugs zanubrutinib or acalabrutinib are more likely to cause a heart rhythm problem called atrial fibrillation. Researchers will analyze health records from 15,000 adults with chronic B-cell cancers. The goal is to help doctors choose the sa…

This study will test a new screening program to find 50-year-olds in Italy who are at risk for type 2 diabetes and heart disease but haven't been diagnosed yet. About 3,000 people will be invited for a check-up using simple questionnaires. Based on their risk scores, they'll get …

This study will follow nearly 6,000 adults in Italy who are prescribed inclisiran, evolocumab, or alirocumab for high cholesterol or heart disease. Researchers want to see how consistently patients take these medications over time in everyday practice. The goal is to understand r…

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in older adults with heart disease. Researchers will study 210 patients aged 65 and older to find common risk factors and understand how these issues affe…

This study collects basic health information like blood pressure, heart rhythm, and weight from 50 adults aged 18-64. The data will help researchers develop a new device that can monitor blood pressure continuously without needles or cuffs. Participants do not receive any treatme…

This study looks at how mothers and babies respond to stress together after birth, and whether that affects their future heart health. Researchers will measure heart activity in 40 mother-infant pairs during a mild stress task. Some mothers took a mindfulness class during pregnan…

This study looks at how two diabetes and weight-loss drugs, semaglutide and tirzepatide, affect blood vessels and heart function directly—not just through weight loss. Researchers will give the drugs to 112 adults with different body weights and blood pressure levels, then measur…

This study looks at whether the supplement quercetin can help blood vessels work better in people with obesity. Researchers will measure how small blood vessels respond to certain substances. 40 participants aged 18-40 with a BMI over 30 will be involved. The goal is to understan…

This study looks at how the loss of estrogen after menopause might increase the risk of heart disease. Researchers will measure blood pressure, nerve activity, and signs of inflammation in 20 healthy postmenopausal women. The goal is to understand the link between estrogen defici…

This study will test a new type of heart MRI that can see tiny details in heart muscle, like early damage or healing. Researchers will compare these images with standard tests in 1000 adults with and without heart disease. The goal is to learn which markers are best for spotting …

This pilot study tests whether a heart health education program made just for women can improve their knowledge, quality of life, and healthy habits. About 50 women with heart disease who are already in cardiac rehab will either get the special program plus usual care, or usual c…

This study will follow one million adults aged 30-74 in Hubei, China, for up to 10 years. Researchers will collect health data and Traditional Chinese Medicine (TCM) body types to see how they relate to chronic diseases like heart disease, cancer, and diabetes. The goal is to cre…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) is linked to multiple chronic conditions such as high blood pressure, diabetes, and heart disease. Participants will have regular health check-ups, blood an…

This study will follow 300 people with stage 4 chronic kidney disease for 18 months to see if high levels of lipoprotein(a) in the blood are linked to heart attacks, strokes, or worsening kidney function. Researchers want to know if this test can better predict heart risk than st…