CARDIOVASCULAR DISEASES

This study tested a new drug called tovinontrine in 303 adults with chronic heart failure (a condition where the heart doesn't pump as well as it should). The goal was to see if the drug could lower a key marker of heart strain (NT-proBNP) compared to a placebo. The trial has com…

This study tested a new device called NEURESCUE that uses a balloon to redirect blood flow to the heart and brain during cardiac arrest. Six adults who were not responding to standard CPR received the device. The main goal was to see if doctors could inflate the balloon within 10…

This study tested a virtual world-based cardiac rehabilitation program called "Destination Cardiac Rehab" against traditional in-person rehab. Nearly 2,900 heart patients participated to see if the virtual program was as good or better at improving heart health and keeping people…

This study tested a special coaching program for older adults (70+) who had a heart problem like a heart attack or heart surgery. The program aimed to help them take part in and benefit more from standard cardiac rehab. 416 people took part, and the study measured how well they c…

This study tested whether a chewing gum containing dietary nitrate (like in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo gum for three weeks…

This study looked at whether a whole food plant-based diet, low in red and processed meats, can lower LDL (bad) cholesterol in adults with heterozygous familial hypercholesterolemia (HeFH), a genetic condition that causes high cholesterol. Fifty participants followed either a pla…

This early-stage study tested a single dose of Kylo-11 in 71 healthy adults with high levels of Lp(a), a protein linked to heart disease. The main goal was to check safety and how the drug moves through the body. Researchers also looked at whether Kylo-11 could lower Lp(a) levels…

This study tested whether the statin drug pitavastatin could lower the risk of heart attacks, strokes, and other serious heart problems in over 7,700 adults with HIV who were already on HIV treatment. Participants were randomly assigned to take either pitavastatin or a placebo pi…

This study tested whether a tighter blood pressure target (below 135/85 mmHg) is better than usual care (below 150/100 mmHg) for women who had high blood pressure during pregnancy. 61 women were enrolled and followed for 6 months after giving birth. The goal was to see if this ap…

This study tested whether two common blood pressure medicines (ACE inhibitors or ARBs) could help high-risk COVID-19 patients avoid intensive care, a ventilator, or death. About 372 adults with COVID-19 and heart disease risk factors took part. Researchers tracked outcomes like I…

This study tested a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to see if it can safely lower blood pressure in people whose hypertension is not controlled by up to three medications. The study involved 337 participants and meas…

This study tested new methods to prevent low blood pressure during dialysis in 1,431 people with kidney failure. Clinics used special training and patient education to make dialysis sessions safer. The goal was to reduce risks and improve comfort during treatment.

This study tested a new medicine called olezarsen in about 1,500 adults with very high triglycerides (a type of blood fat) who also had heart disease or were at high risk for it. The goal was to see if olezarsen could lower triglyceride levels more than a placebo over 25 weeks. P…

This study tested a nurse-led phone program to help 500 recent stroke patients in Ghana control their blood pressure. High blood pressure is a major risk factor for another stroke. The program used mobile health technology and regular nurse calls to support patients in managing t…

This study tested a new medicine called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if it safely lowers a key heart stress marker (NT-proBNP) compared to a placebo. Participants took the drug or placebo for 12 weeks, and …

This study looked at 150 women who finished breast cancer treatment and are now on hormone therapy. Researchers wanted to see if teaching them about a Mediterranean diet and encouraging physical activity could improve their heart health and weight. The program included diet advic…

This study tested a device called MitraClip that clips a leaky heart valve to help it close better. 304 people with severe mitral regurgitation and heart failure were randomly assigned to get either standard care alone or standard care plus the MitraClip procedure. The goal was t…

This study looked at whether intensive dental cleaning (scaling and root planing) can improve not only oral health but also markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers…

This study tested the SAPIEN XT heart valve in 57 people whose right heart valve was leaky or narrowed. The goal was to see if the valve was safe and worked well. Most participants had a history of congenital heart disease.

This study tested a new way to treat high blood pressure without pills. Doctors used focused ultrasound to modify fat around the kidney in 79 patients with mild hypertension who were not on medication. The goal was to see if this procedure could safely lower blood pressure compar…

This study tested an experimental pill called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. About 687 adults with PAH took either ralinepag or a placebo on top of their usual treatments. The goal was …

This study tested whether using social networks (like WeChat) can help people at high risk for stroke take their medications correctly after leaving the hospital. 720 participants were split into two groups: one received standard care, the other got extra support through social n…

This study looked at whether a 16-week strength training program can help adults who had a bone marrow transplant as children. The goal was to see if exercise can reduce muscle loss, heart disease, and diabetes risks that often appear years after transplant. 28 survivors and heal…

This study tested a drug called alirocumab in 118 adults with HIV who were at risk for heart disease. The goal was to see if the drug could reduce inflammation in the arteries and improve blood vessel function. Participants received either the drug or a placebo for about a year, …

This study tested a digital quality improvement program to help doctors better manage LDL (bad) cholesterol in patients with heart disease. Over 1,400 adults in Brazil with established cardiovascular disease participated. The program used smartphone tools to improve treatment and…

This study looked at whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes or pre-diabetes who recently had a heart attack or stroke. Inflammation is a key driver of artery plaque buildup, which can lead to more heart problems. …

This study looked at how different amounts of aerobic exercise affect heart disease patients in a cardiac rehab program. 115 participants were monitored for changes in skin blood flow, oxygen use, and weight. The goal was to see how exercise helps manage heart disease.

This study tested whether giving heart attack patients remote monitoring devices to use at home could reduce the need for hospital readmissions. 337 participants with high cardiovascular risk took part. The goal was to see if telemedicine could safely provide necessary care witho…

This study tested a special walking program for people who had a stroke at least six months ago. The program combined robot-assisted walking practice with regular walking training to help improve how they walk, manage their weight, and control blood pressure. A total of 140 parti…

This study looked at whether drinking Dachundou No Sugar Added Soymilk every day for 8 weeks can lower cholesterol in adults with high cholesterol. 25 participants drank two bottles of soymilk daily. Researchers measured cholesterol, blood pressure, and other health markers. The …

This study tested whether sending educational text messages to people who had a heart attack could help them control risk factors like blood pressure and cholesterol, and prevent future heart problems. 370 patients participated and received text messages for one year. The goal wa…

This study tested a new device called the Supernova stent retriever in 54 people having a severe stroke caused by a large blood clot in the brain. The device is designed to grab and remove the clot, restoring blood flow. The main goals were to see if the device could safely reope…

This early-phase study tested a new compound given under the tongue to see if it can lower blood pressure by boosting nitric oxide levels. Fourteen healthy adults took part. The goal was to measure changes in blood pressure and related chemicals in the blood. This approach might …

This study tested a new method to stop bleeding after a common heart procedure (transradial catheterization). The goal was to reduce the chance of artery blockage and bleeding while shortening the time pressure is needed. 451 adults took part, and the approach combined a lower do…

This study tested a once-daily pill called orforglipron against insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had higher heart risk. The goal was to see if the pill is safe and effective at controlling blood sugar and preventing…

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for diabetes and heart disease. Researchers compared normal-weight and overweight/obese South Asian adults who sit at least 7…

This study tested a tiny balloon catheter designed to open completely blocked heart arteries (chronic total occlusions) before placing a stent. 170 adults with coronary artery disease took part. The main goal was to see if the balloon could be safely delivered, inflated, and remo…

This large study tested whether taking two blood-thinning medications (clopidogrel plus aspirin) is more effective than taking just aspirin alone for patients with multiple blocked heart arteries who received a stent. The goal was to see if the two-drug combination better prevent…

This study looked at whether a simple checklist called the YEARS algorithm can safely rule out dangerous blood clots in the lungs (pulmonary embolism) in people with active cancer, without needing a CT scan. About 700 participants were randomly assigned to either the YEARS approa…

This study tested a lifestyle program designed for rural families at high risk for heart disease and type 2 diabetes. Over 500 Hispanic and non-Hispanic adults participated, focusing on healthy eating, physical activity, and weight management. The goal was to see if a culturally …

This study looked at whether a home-based physical activity program and computer-based cognitive training, alone or together, could prevent memory loss in older women with heart disease. 253 women aged 65 and older with cardiovascular disease but no regular exercise or cognitive …

This study tested a 6-month program that taught nutrition and exercise to 50 mothers and children in vulnerable communities in Mexico's Yaqui Valley. The goal was to improve lifestyle habits and reduce risks for heart disease and type 2 diabetes. Researchers measured weight, bloo…

This study tested whether giving people their 'heart age' and genetic risk scores, along with a digital behavior-change app, could help them reduce their risk of heart disease. Over 1,100 adults aged 30-74 with at least a 5% risk of heart disease participated. The goal was to see…

This study tested whether a technique called evaluative conditioning could help people who had a heart attack exercise more intensely during cardiac rehab. Twenty-four patients were split into two groups: one received conditioning linked to physical activity, the other to diet. T…

This study looked at whether a 12-week program of aerobic and strength exercises could improve heart health and fitness in women who finished treatment for endometrial cancer. 33 survivors participated. The goal was to see if exercise helps blood vessels work better and reduces h…

This study tested a program to help young adult cancer survivors (ages 18-39) with obesity lose weight and manage symptoms like pain, fatigue, and distress. The goal was to reduce their risk of heart disease. 38 survivors took part in a pilot trial to see if the program was feasi…

This study tested whether a 12-week virtual exercise program (high-intensity or moderate-intensity) could improve physical and mental health in 20 women with cardiac implantable electronic devices. The goal was to see if such programs are feasible and beneficial for this group. R…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without symptoms) increases the risk of heart-related death or problems in people with coronary heart disease. Researchers followed participants for one to three years to track outcomes. The …

This study looked at how quickly cutting back on physical activity for just 3 days can harm blood vessel function and raise blood sugar after meals in active older adults (55+). Researchers compared them to younger adults (18-40) to see if age makes the effects worse. The goal is…

This study tested a school program called Healthy School Recognized Campus in Texas elementary schools. Researchers wanted to see if the program could improve kids' heart health by encouraging physical activity and better nutrition. About 159 students in 5th and 6th grade took pa…

This study tested four simple behavior change techniques—goal setting, action planning, self-monitoring, and feedback—to see if they could help sedentary adults at risk for heart disease walk at least 1,000 more steps per day. Over 600 participants used a Fitbit and received text…

This study examined whether people with high levels of lipoprotein (a), a type of fat in the blood, have different amounts of stem cells that help repair blood vessels. Researchers compared blood samples from 40 adults with high Lp(a) (≥100 nmol/L) to those with normal levels. Th…

This study looked at whether older African Americans (55+) with heart disease risk factors could follow a special diet called MIND+SOUL. The diet combines brain-healthy foods with soul food traditions. Researchers measured how many people stuck with the diet and checked changes i…

This study followed 6,000 adults who had COVID-19 symptoms to see how their health changed over 18 months. Participants completed online surveys every 3 months. The goal was to learn about long-term problems like chronic fatigue or heart issues, not to test a treatment.

This study looked at whether fatty liver disease can help predict heart disease risk beyond traditional factors. Researchers measured blood markers of blood vessel damage in 63 adults aged 50-69 at high cardiovascular risk. The goal was to better understand the link between liver…

This pilot study tested a program called AIRWISE in 20 adults aged 55 and older with heart disease. The program provided air cleaners, air quality monitors, and education to improve indoor air. The goal was to see if people would use these tools and if they helped heart health. T…

This study looked at 485 patients who had coronary artery bypass surgery to see if a computer method called fuzzy logic could better predict who might die after the operation. Fuzzy logic mimics human reasoning to handle uncertain information, like a doctor's experience. The goal…

This study reviewed health records of 2,039 people from racial/ethnic minority groups who have HIV to see if seeing a heart specialist helps prevent heart disease. Researchers tracked who visited a cardiologist and compared heart outcomes over up to 5 years. The goal is to learn …

This study looked at how well Arab women in East Jerusalem understand health information and how to talk with their doctors. About 306 women took part in focus groups and workshops. The goal was to see if the workshops could improve their knowledge of heart disease and their conf…

This study looked at over 1,600 people with giant cell arteritis (GCA), a condition that causes inflamed blood vessels. Researchers compared two drugs, tocilizumab and methotrexate, to see which one better prevents major heart problems like heart attacks, strokes, or death. Using…

This study looked at how a four-week ketogenic diet changes cholesterol levels and heart health in healthy adults with a normal weight compared to those with obesity. Researchers wanted to see if the diet raises 'bad' cholesterol more in lean people and harms blood vessel functio…

This study followed over 18,000 Taiwanese adults to see if a vegetarian diet is linked to lower rates of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers used health insurance records to trac…

This study looked at nearly 242,000 adults with type 2 diabetes to find out which glucose-lowering medications are best for heart health and other important outcomes. Researchers also examined whether benefits differ by age, sex, race, or kidney function. The goal is to help pati…

This study looked at why people with rheumatoid arthritis (RA) often miss out on cholesterol checks and treatments that can prevent heart attacks and strokes. Researchers worked with 101 patients aged 40-75 to identify barriers and develop a support program including education an…

This study gathered information from 100 adults undergoing a standard heart procedure to help evaluate a software tool that analyzes echocardiograms. No new treatments or tests were given—only routine care data was used. The goal was to see how well the software measures parts of…

This study looked at two methods for assigning care coordinators to older adults (65+) with heart disease or risk factors like diabetes and high blood pressure. The goal was to see which approach better prevented emergency room visits and hospitalizations. Researchers compared as…

This study looked at how well Hodgkin lymphoma survivors' hearts and lungs work during exercise. It tested whether a fitness program could improve their physical capacity and heart function. Forty adult survivors who had chemotherapy and chest radiation at least five years ago to…

This study looked at whether eating fewer ultra-processed foods (like packaged snacks and sugary drinks) can improve blood vessel function in middle-aged adults. Seventeen participants followed either a low or high processed food diet for six weeks. The goal was to see if this ch…

This study looked at whether certain gene changes make sudden cardiac death more likely. Researchers checked DNA from 2500 people for links to heart rhythm problems. The goal was to find genetic clues that could help predict risk, not to test a treatment.

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and factors like mood and kitchen access to understand why weight gain happens. The goal is to use this information to design better he…

This study looked at whether a simple audit-and-feedback tool could help elementary schools in Oakland, California, follow physical education (PE) laws more closely. The goal was to increase students' physical activity and reduce health gaps. Researchers worked with 35 schools th…

This study tested a program called GRACE that helps people understand their genetic risk for diseases like heart disease, cancer, and liver disease. Researchers worked with 245 patients, their doctors, and family members in primary care clinics, including those with limited resou…

This study tested a wellness program for long-term care workers to see if it could lower stress and improve heart health. About 159 staff and residents took part. The program focused on healthy habits like diet, exercise, and stress management, and also looked at whether staff ac…

This study looked at how heart disease and mental health problems like depression and anxiety are connected, and how things in the environment might play a role. Researchers studied 400 people with both heart disease and a mental health condition, using questionnaires and tests t…

This study checked whether a depression questionnaire called the Cardiac Depression Scale works well in Turkish people with heart disease. 360 adults with stable heart conditions filled out the long and short forms. The goal was to make sure the scale is accurate and reliable for…

This study tested whether giving African American patients in rural eastern North Carolina a personalized list of local resources (like food, housing, and transportation help) could improve their confidence in managing their heart health. Over 300 participants received a 'Healthe…

This study looked at whether information from social media, online searches, and mobile devices can help predict a person's risk for heart disease. Researchers analyzed the language and topics in posts from 781 adults aged 30-74. The goal was to see if digital data could improve …

This study looked at whether certain blood markers can predict serious heart problems like heart attack or death after a stent procedure. Researchers measured two types of cells in the blood that reflect blood vessel injury and healing. They followed 170 adults for up to a year t…

This study looked at whether replacing sitting time with standing or walking can help control blood sugar in South Asian adults who are overweight or obese. Eighteen participants changed their daily routines to sit less and move more. The results showed that even small changes ca…

This study looked at how a high-dose fish oil supplement (E-EPA) affects cholesterol and blood fats in 68 healthy adults aged 18-65. Participants took the supplement daily for one month while eating normally. Researchers measured changes in LDL cholesterol stickiness and blood tr…

This study looked at 320 adults who had heart surgery to see how well two risk scores (EuroSCORE-II and POSPOM) predict death in the hospital. Researchers used past medical records and did not give any new treatments. The goal is to find out which score is more reliable for plann…

This study looked at whether a simple phone call from a medical student to older adults with heart disease or mental health conditions could reduce hospitalizations during the first COVID-19 lockdown in France. Over 22,000 patients were randomly assigned to receive a check-in cal…

This study tested a new tool that calculates a person's risk of heart disease. It was used in GP surgeries with 862 people aged 45-64 who were already due for a heart health check. The goal was to see if the tool works well in everyday practice and if doctors and patients find it…

This study looked at 1,000 people who had a heart attack to understand why some had no common risk factors like smoking, high blood pressure, or diabetes. Researchers compared those with and without these risk factors to find new clues in blood tests, imaging, and health history.…

This study looked at how social factors like income, housing, and stress, along with depression, affect blood vessel health in 105 low-income racial and ethnic minority adults. Participants completed questionnaires about their mental health, social needs, and lifestyle. The goal …

This study looked at whether a supplement called MitoQ can improve blood vessel function and lower blood pressure in Black and non-Black adults aged 45-75. Researchers wanted to understand if problems with tiny energy-producing parts of cells (mitochondria) help explain why Black…

This small study looked at whether drinking a KETO5 XOGenius beverage daily could improve markers of heart and brain health in 6 healthy adults aged 18-50. Researchers measured blood pressure, cholesterol, artery stiffness, and cognitive function. The goal was to gather initial d…

This study aimed to improve genetic counseling for people of all backgrounds. Over 1,000 participants completed surveys and allowed their counseling sessions to be audio recorded. Researchers tested different counseling approaches to see which led to better patient experiences. T…

This study tested whether a Fitbit activity tracker plus health coaching could help people with overweight or obesity who are already taking weight loss medications (GLP-1/GIP) become more active. Fifteen patients from a primary care clinic participated in a 12-week program where…

This research study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. Fifteen adults with overweight or obesity took part. The goal was to learn more about what helps or hinders weight management in th…

This study looked at ways to help Black older adults with type 2 diabetes sit less and move more. Researchers worked with 33 participants to understand their habits and design practical strategies. The goal was to improve heart health and reduce diabetes complications.

This study looked at whether having a doctor send an online referral to a food program called WIC helps more pregnant women sign up. About 240 pregnant women on Medicaid or without insurance took part. Some got usual care, others got a direct referral, and some also spoke with a …