New genomic risk model aims to make personalized prevention accessible to all

NCT ID NCT06278883

Completed Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a program called GRACE that helps primary care patients assess their risk for diseases like heart disease, cancer, and liver disease using family health history. Researchers enrolled 245 patients from five clinics, including low-resource settings, to see how many completed the risk assessment and followed up on genetic counseling or testing. The goal is to make genomic medicine more accessible and reduce health disparities.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Disease Risk Assessment (behavioral intervention using family health history and genetic testing recommendations)
What this could lead to: If successful, this model could help more people in low-resource settings get personalized risk assessments for diseases like heart disease and cancer, potentially leading to earlier detection and prevention.
What could go wrong: This is a completed implementation study, not a treatment trial. It measures how well the risk assessment works in practice, not whether it directly improves health outcomes. Results may vary across different clinics and populations.

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Conditions

The condition(s) this trial relates to.

cancer cardiovascular disorder Hyperthermia liver disorder neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CARDIOVASCULAR DISEASES HYPERTHERMIA LIVER DISEASES

Contacts and locations

Locations

UF Health Augustine Oaks

Jacksonville, Florida, 32258, United States
UF Health Family Medicine - Commonwealth

Jacksonville, Florida, 32254, United States
UF Health Family Medicine - Lem Turner

Jacksonville, Florida, 32208, United States
UF Health Oakleaf

Orange Park, Florida, 32065, United States

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