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Can a Tight-Control strategy tame lupus?

NCT ID NCT05714930

Recruiting now Disease control Sponsor: Heinrich-Heine University, Duesseldorf Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 'treat-to-target' approach—where doctors adjust treatment every 6 weeks to aim for remission—works better than usual care for people with lupus. About 606 participants who are not in remission will be followed for 120 weeks. The goal is to see if this strategy reduces long-term organ damage and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
treat-to-target strategy (tight control with frequent visits and treatment adjustments)
What this could lead to
If successful, this approach could become a standard way to manage lupus, helping more patients reach remission and prevent long-term organ damage.
What could go wrong
This is a strategy trial, not testing a new drug, so benefits may be modest. Results depend on how well doctors and patients follow the plan, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

  • Charité - Berlin University of Medicine

    RECRUITING

    Berlin, 10117, Germany

  • Kliniken Essen Mitte, Essen

    RECRUITING

    Essen, North Rhine-Westphalia, 45136, Germany

  • LMU Munich

    RECRUITING

    Munich, Bavaria, 80336, Germany

  • Medical University Hannover

    RECRUITING

    Hanover, Lower Saxony, 30625, Germany

  • Rheumazentrum Ruhrgebiet Herne, Ruhr University Bochum

    RECRUITING

    Herne, North Rhine-Westphalia, 44649, Germany

  • UKSH Campus Kiel

    RECRUITING

    Kiel, 24105, Germany

  • University Clinic Düsseldorf

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • University Clinic Erlangen

    NOT_YET_RECRUITING

    Erlangen, Bavaria, 91054, Germany

  • University Clinic Frankfurt

    RECRUITING

    Frankfurt am Main, Hesse, 60590, Germany

  • University Clinic Freiburg

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • University Clinic Heidelberg

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • University Clinic Mainz

    RECRUITING

    Mainz, Rhineland-Palatinate, 55131, Germany

  • University Clinic Münster

    RECRUITING

    Münster, North Rhine-Westphalia, 48149, Germany

  • University Medical Center TU Dresden

    RECRUITING

    Dresden, Saxony, 01307, Germany

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