Heart valve trial asks: do we really need that extra artery test?
NCT ID NCT06898086
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at people with severe aortic stenosis who need a new heart valve (TAVI). Normally, doctors do a coronary angiogram first to check for blocked arteries. But this test can cause kidney damage or bleeding, especially in older patients. The trial will compare the usual approach to a simpler one without the angiogram, to see if it is just as safe and effective. About 620 participants across Europe will be followed for two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcatheter aortic valve implantation (TAVI) using the Myval™ heart valve
What this could lead to
If successful, this could simplify the TAVI procedure for many patients, reducing risks like kidney injury and bleeding from unnecessary angiography.
What could go wrong
This is a non-inferiority trial, so it may only show that skipping angiography is not worse than the standard approach. The results may not apply to patients with chest pain or those who had prior coronary procedures.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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AOUP- Azienda Ospedaliera Universitaria Pisana
NOT_YET_RECRUITINGPisa, Basel-Stadt, 56126, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliera Universitaria Senese
NOT_YET_RECRUITINGSiena, 53100, Italy
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Contact
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Azienda Ospedaliero Policlinico Universitaria G. Rodolico- San Marco Catania
NOT_YET_RECRUITINGCatania, 95123, Italy
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Azienda Sanitaria Universitaria Integrata di Trieste
NOT_YET_RECRUITINGTrieste, 34128, Italy
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Clinical Trial Center Maastricht B.V
NOT_YET_RECRUITINGMaastricht, 6229, Netherlands
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Clinique Pasteur
NOT_YET_RECRUITINGToulouse, 31076, France
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Elisabeth Krankenhaus Essen
NOT_YET_RECRUITINGEssen, 45138, Germany
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Fondazione Policlinico Universitario Campus Biomedico
RECRUITINGRoma, 00128, Italy
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IRCCS ISMETT Palermo
NOT_YET_RECRUITINGPalermo, Basel-Stadt, 90127, Italy
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Institut Arnault Tzanck
NOT_YET_RECRUITINGNice, 06700, France
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Klinikum Klagenfurt am Wörthersee
NOT_YET_RECRUITINGKlagenfurt, 9020, Austria
Contact
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Královské Vinohrady University Hospital
NOT_YET_RECRUITINGPrague, 10034, Czechia
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Medical University Graz
RECRUITINGGraz, 8036, Austria
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Nemocnice Na Homolce
NOT_YET_RECRUITINGPrague, 15030, Czechia
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OLVG Hospital Amsterdam
NOT_YET_RECRUITINGAmsterdam, 1091, Netherlands
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Ospedale dell'Angelo - ULSS 3 Serenissima
NOT_YET_RECRUITINGMestre, 30174, Italy
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Stichting Amsterdam UMC
NOT_YET_RECRUITINGAmsterdam, 1081, Netherlands
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University Hospital Basel
RECRUITINGBasel, Canton of Basel-City, 4031, Switzerland
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University Hospital Zurich
NOT_YET_RECRUITINGZurich, 8091, Switzerland
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Universitätsklinikum Düsseldorf
NOT_YET_RECRUITINGDüsseldorf, North Rhine-Westphalia, 40221, Germany
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Universitätsklinikum Freiburg- Universitäts-Herzzentrum Campus Bad Krozingen
NOT_YET_RECRUITINGFreiburg im Breisgau, 79189, Germany
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Universitätsklinikum Schleswig-Holstein - Campus Lübeck
NOT_YET_RECRUITINGLübeck, 23562, Germany
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Universitätsklinikum Ulm
NOT_YET_RECRUITINGUlm, 89081, Germany
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