Second chance: can a new valve fix a failing TAVR without open surgery?

NCT ID NCT06777368

Recruiting now Disease control Sponsor: Medtronic Cardiovascular Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for people whose first TAVR heart valve is failing. Doctors will place a new TAVR valve inside the old one. The goal is to see if this 'redo' procedure is safe and works well. About 225 people will take part, and researchers will check how the valve performs at 30 days and one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Medtronic TAV or Edwards TAV device
What this could lead to: If successful, this could provide a proven way to replace a failing TAVR valve without open-heart surgery, offering a safer option for patients.
What could go wrong: This is a relatively small, early-stage study (225 people) focused on safety and device performance. The procedure carries risks like stroke, heart damage, or need for further surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS

Contacts and locations

Locations

Abbott Northwestern/Minneapolis Heart
RECRUITING

Minneapolis, Minnesota, 55407, United States
Abrazo Arizona Heart Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Ascension Seton Medical Center Austin
RECRUITING

Austin, Texas, 78705, United States
Ascension Via Christi St. Francis
RECRUITING

Wichita, Kansas, 67214, United States
Astrium Health Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Aurora St. Lukes Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Baylor Saint Luke's (The Texas Heart Institute)
RECRUITING

Houston, Texas, 77030, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02135, United States
Buffalo General Medical Center
RECRUITING

Buffalo, New York, 14203, United States
Catholic Medical Center
RECRUITING

Manchester, New Hampshire, 03102, United States
CentraCare Heart and Vascular Center
RECRUITING

Saint Cloud, Minnesota, 56303, United States
Corewell Health (Spectrum)
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Froedtert Hospital
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
HealthPark Medical Center, Lee Memorial Health
RECRUITING

Fort Myers, Florida, 33908, United States
Heart Hospital of Austin
RECRUITING

Austin, Texas, 78705, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Kaiser Permanente Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90027, United States
Kaiser Permanente Northern California
RECRUITING

Sacramento, California, 95825, United States
Lankenau Medical Center
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Lehigh Valley Hospital
RECRUITING

Allentown, Pennsylvania, 18103, United States
Los Robles Regional Medical Center
RECRUITING

Thousand Oaks, California, 91360, United States
Maine Medical Center
RECRUITING

Portland, Maine, 04102, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Washington Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical Center of the Rockies
RECRUITING

Loveland, Colorado, 80538, United States
Medstar Union Memorial Hospital
RECRUITING

Baltimore, Maryland, 21218, United States
MercyOne Iowa Heart Center
RECRUITING

Des Moines, Iowa, 50314, United States
Methodist Hospital
RECRUITING

San Antonio, Texas, 78229, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Morton Plant Hospital
RECRUITING

Clearwater, Florida, 33756, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
NYU Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Northwell Health
RECRUITING

Manhasset, New York, 11030, United States
OhioHealth Riverside Methodist Hospital
RECRUITING

Columbus, Ohio, 43214, United States
Oklahoma Heart Hospital
RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Orlando Health/Orlando Regional Medical Center
RECRUITING

Orlando, Florida, 32806, United States
Parkview Health
RECRUITING

Fort Wayne, Indiana, 46845, United States
Providence Heart Institute (Providence Sacred Heart)
RECRUITING

Spokane, Washington, 99204, United States
Providence Saint Patrick Hospital
RECRUITING

Missoula, Montana, 59802, United States
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States
Saint Francis Hospital
RECRUITING

Roslyn, New York, 11576, United States
Saint Vincent Heart Center of Indiana
RECRUITING

Indianapolis, Indiana, 46290, United States
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
St. Luke's Hospital of Kansas City
RECRUITING

Kansas City, Missouri, 64111, United States
St. Thomas West Hospital
RECRUITING

Nashville, Tennessee, 37205, United States
Stanford Hospital & Clinics
RECRUITING

Stanford, California, 94305, United States
Sutter Heatlh
RECRUITING

Sacramento, California, 95816, United States
Tampa General/USF
RECRUITING

Tampa, Florida, 33606, United States
The Christ Hospital
RECRUITING

Cincinnati, Ohio, 45219, United States
The Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
The University of Kansas
RECRUITING

Kansas City, Kansas, 66103, United States
The Valley Hospital
RECRUITING

Paramus, New Jersey, 07652, United States
TriStar Centennial Medical Center
RECRUITING

Nashville, Tennessee, 37203, United States
Tucson Medical Center
RECRUITING

Tucson, Arizona, 85712, United States
UPMC Pinnacle
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Presbyterian
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University Hospitals of Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Michigan Health
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77479, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Virginia Medical Center
RECRUITING

Charlottesville, Virginia, 22908, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 05610, United States

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