New blood thinner may simplify life after valve replacement
NCT ID NCT04258488
First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times
Summary
This study tests whether a newer blood thinner (rivaroxaban) works as well as the standard drug (warfarin) for preventing clots and bleeding in people who have a mechanical aortic valve. About 1,300 adults who had valve surgery at least 3 months ago will take one of the two pills daily for a year. The goal is to see which drug better prevents serious heart problems and bleeding complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rivaroxaban (oral blood thinner)
- What this could lead to
- If successful, this could offer a simpler, more predictable blood-thinning option for people with mechanical aortic valves, potentially reducing the need for frequent blood tests.
- What could go wrong
- This is a phase 4 trial, so the drug is already approved for other uses, but its safety and effectiveness for this specific valve type are not yet proven. There is a risk of bleeding or clotting events.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ajou University Hospital
RECRUITINGSuwon, South Korea
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Asan Medical Center
RECRUITINGSeoul, 138-736, South Korea
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Buchen Sejong Hospital
RECRUITINGBucheon-si, South Korea
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Chonnam National University Hospital
RECRUITINGGwangju, South Korea
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Dong-A University Hospital
RECRUITINGBusan, South Korea
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Eulji University Uijeongbu Hospital
RECRUITINGUijeongbu-si, South Korea
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GangNeung Asan Hospital
RECRUITINGGangneung, South Korea
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Keimyung University Dongsan Hospital
RECRUITINGDaegu, South Korea
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Korea University Anam Hospital
RECRUITINGSeoul, South Korea
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Pusan National University Yangsan Hospital
RECRUITINGYangsan, South Korea
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Samsung Medical Center
RECRUITINGSeoul, South Korea
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Seoul National University Bundang Hospital
RECRUITINGSeongnam, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, South Korea
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Severance Hospital
NOT_YET_RECRUITINGSeoul, South Korea
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St. Vincent's Hospital, Catholic University of Korea
NOT_YET_RECRUITINGSuwon, South Korea
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Ulsan University Hospital
NOT_YET_RECRUITINGUlsan, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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