Can a simple drug make colorectal surgery safer?
NCT ID NCT06657924
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving tranexamic acid (TXA) before and after major colorectal surgery can reduce bleeding and the need for blood transfusions. About 394 adults having inpatient colorectal surgery will either receive TXA or not. The trial also checks if TXA raises the risk of blood clots.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tranexamic acid (TXA)
- What this could lead to
- If it works, this could become a standard way to reduce bleeding and transfusions in colorectal surgery.
- What could go wrong
- This is a mid-stage trial with 394 participants, so results may not apply to all patients. TXA could increase the risk of dangerous blood clots.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cleveland Clinic Fairview Hospital
RECRUITINGCleveland, Ohio, 44111, United States
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