Heart surgery may reshape your gut microbiome

NCT ID NCT07052071

Recruiting now Knowledge-focused Sponsor: Hippocration General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether replacing a narrowed heart valve (TAVI) changes the types of bacteria living in the gut. Researchers will collect stool and blood samples from 40 patients before and after the procedure. The goal is to see if improved blood flow from the new valve helps restore a healthier gut microbiome, which could open new doors for heart disease treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcatheter Aortic Valve Implantation (TAVI) procedure
What this could lead to: If successful, this could reveal a connection between heart function and gut health, pointing toward new ways to treat cardiovascular disease by targeting the microbiome.
What could go wrong: This is a small, early observational study with only 40 participants. It looks at changes in gut bacteria, not direct treatment outcomes, so results may not lead to immediate medical advances.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS GUT MICROBIOME GUT MICROBIOTA TAVI TAVI(TRANSCATHETER AORTIC VALVE IMPLANTATION)

Heart surgery may reshape your gut microbiome

Summary

What this could mean

Get notified about this study

Conditions

As listed by the trial registrant

Contacts and locations

Locations

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