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Gentler Heart-Lung machine tested in 1,300-Patient trial

NCT ID NCT05487612

Recruiting now Disease control Sponsor: Aristotle University Of Thessaloniki Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a newer, minimally invasive heart-lung machine (MiECC) to the standard machine used during heart surgery. Researchers want to see if the newer machine reduces serious problems like heart attack, stroke, or kidney injury. About 1,300 adults having elective heart surgery will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Minimally invasive extracorporeal circulation (MiECC) device
What this could lead to
If successful, this could show that a newer, gentler heart-lung machine reduces serious complications after heart surgery, leading to better recovery.
What could go wrong
This is an early-stage comparison, not a cure. The device may not prove significantly better than the standard approach, and individual results vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS CORONARY ARTERY DISEASE EXTRACORPOREAL CIRCULATION; COMPLICATIONS

Contacts and locations

Locations

  • Cardiothoracic Department AHEPA University Hospital

    RECRUITING

    Thessaloniki, 54636, Greece

  • Deparment of Cardiac Surgery, Castle Hill Hospital

    ACTIVE_NOT_RECRUITING

    Hull, HU16 5JQ, United Kingdom

  • Department of Cardiac Surgery

    ACTIVE_NOT_RECRUITING

    Coswig, 06869, Germany

  • Department of Cardiac Surgery GVM Anthea Hospital

    RECRUITING

    Bari, 70124, Italy

  • Department of Cardiac Surgery GVM Maria Eleonora Hospital

    ACTIVE_NOT_RECRUITING

    Palermo, 90135, Italy

  • Department of Cardiac Surgery, Royal Papworth Hospital

    ACTIVE_NOT_RECRUITING

    Cambridge, CB2 0AY, United Kingdom

  • Department of Cardiothoracic Surgery, Hammersmith Hospital

    ACTIVE_NOT_RECRUITING

    London, W120HS, United Kingdom

  • Department of Cardiothoracic and Vascular Surgery, Ulm University Hospital

    COMPLETED

    Ulm, 89081, Germany

  • Department of Cardiovascular Surgery, Ankara City Hospital

    ACTIVE_NOT_RECRUITING

    Ankara, Turkey (Türkiye)

  • Department of Cardiovascular Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University

    RECRUITING

    Rize, Turkey (Türkiye)

  • Department of Cardiovascular Surgery, Izmir Bakırçay University, Faculty of Medicine

    RECRUITING

    Izmir, Turkey (Türkiye)

  • Department of Thoracic and Cardiovascular Surgery, University Medical Centre Goettingen

    ACTIVE_NOT_RECRUITING

    Göttingen, Germany

  • Perfusion Services University Health Network, Toronto General Hospital

    RECRUITING

    Toronto, M5G 2C4, Canada

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