Heart valve patients may ditch blood thinners for simple aspirin

NCT ID NCT07431762

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares aspirin to the blood thinner warfarin in 1058 people who just had a bioprosthetic heart valve replacement. For 6 months after surgery, participants take either daily aspirin or warfarin. The goal is to see if aspirin is just as safe and effective at preventing blood clots, strokes, and other complications, potentially offering a simpler treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

aspirin or warfarin

What this could lead to

If aspirin works as well as warfarin, patients could avoid the frequent blood tests and dietary restrictions needed with warfarin.

What could go wrong

This is a phase 4 trial, so the drugs are already approved, but it's still possible that aspirin is less effective at preventing clots, which could increase stroke risk.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Asan Medical Center

    Seoul, 05505, South Korea

    Contact

  • National Cerebral and Cardiovascular Center Hospital

    Osaka, 564-8565, Japan

    Contact

  • Osaka University Hospital

    Osaka, 565-0871, Japan

    Contact