Gut bacteria could help revive immunotherapy in lung cancer
NCT ID NCT06448572
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether a capsule containing a healthy gut bacterium (EXL01) can boost the effectiveness of the immunotherapy drug nivolumab in people with advanced non-small cell lung cancer that has stopped responding to prior immunotherapy. The study will enroll 21 adults whose cancer has progressed after standard treatments. Researchers will monitor how long the cancer stays under control and track any side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EXL01 (a single strain of the gut bacterium Faecalibacterium prausnitzii) combined with nivolumab
- What this could lead to
- If it works, this could point toward a new treatment option for people with advanced lung cancer whose disease has stopped responding to standard immunotherapy.
- What could go wrong
- This is a very early, small pilot study with only 21 participants, so results may not apply to everyone. The combination may not improve outcomes and could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Lille
RECRUITINGLille, 59000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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