University Hospital, Lille

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. Half the participants will get the usual antibiotics, and half will get none. The …

This study tests whether adding benralizumab (a drug that targets certain immune cells) to standard steroid treatment can help people with DRESS syndrome recover faster and spend fewer days in the hospital. DRESS is a rare, serious reaction to medications that can affect the skin…

This study compares two types of minimally invasive surgery for esophageal cancer: totally minimally invasive esophagectomy (TMIE) and hybrid esophagectomy (HE). The goal is to see which approach leads to fewer severe complications after surgery. About 327 adults with resectable …

This study tests whether freezing precancerous skin spots (cryotherapy) followed by a medicated ointment (tirbanibulin) works better than freezing alone for people with actinic keratosis on the scalp or forehead. About 59 adults with at least 8 spots will receive the combination …

This study tests whether giving steroids for longer or adding N-acetylcysteine can help people with severe alcoholic hepatitis live longer and have better liver function. About 477 adults with severe liver inflammation from heavy drinking will be enrolled. The goal is to see if t…

This study looks at whether a single session of hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce brain damage in people who survive a hanging attempt. About 50 adults will either receive standard intensive care or standard care plus one oxygen…

This study tests a special PET scan (18FET) to find small pituitary tumors that standard MRI scans miss. About 30 adults with hormone-secreting pituitary adenomas will get the scan. If it works, it could help doctors decide on surgery or radiation more accurately.

This study checks whether a blood gas measurement (the difference in carbon dioxide between central veins and arteries) can accurately detect low cardiac output in 74 patients with septic shock from severe skin infections who are receiving hyperbaric oxygen therapy. The goal is t…

This study tests whether using two automated methods together—draining secretions from below the vocal cords and keeping the breathing tube's cuff pressure steady—can reduce the risk of stomach or mouth fluids entering the lungs (microaspiration) in critically ill patients on ven…

This study tests whether giving financial rewards to pregnant women who smoke—and also to their smoking partners—can help them quit. About 180 pregnant women and their partners will be split into three groups to see if adding a partner incentive boosts success. The goal is to red…

This study compares two ways to manage pain after minimally invasive surgery for esophageal cancer: a paravertebral catheter versus the standard epidural. The goal is to see if the paravertebral approach provides similar or better recovery quality by day three. About 506 adults h…

This study tests whether doing broad genetic testing early, instead of later, helps more people with advanced pancreatic, liver, or triple-negative breast cancer get treatments that match their tumor's genetic makeup. About 360 adults with advanced disease will be randomly assign…

This study looks at whether a computer model can find signs of a rare heart condition called cardiac amyloidosis in bone scans that were done for other reasons. Researchers will review past scans from 57 adults and invite those with suspicious findings for further testing. The go…

This study will observe over 13,000 children admitted to 14 French pediatric intensive care units (ICUs). Researchers want to test two scoring systems (PIM3 and PRISM IV) that predict how sick a child is and their chance of survival. They will also look at the cost of care. The g…

This study looks at whether changes in the FLNA gene are linked to emphysema, a lung condition that causes breathing problems. Researchers will examine 70 people with FLNA mutations using lung tests, heart ultrasound, and chest scans. The goal is to find out how common emphysema …

This study looks at how the immune system changes in people with glioblastoma, a serious brain cancer, after they have surgery and chemoradiotherapy. Researchers will take blood samples over six months to measure immune cells and signals. The goal is to understand the body's immu…

This study will follow 400 transgender people for five years to see how different types of medical and psychological support affect their quality of life. Participants will receive standard care, and researchers will track their well-being using surveys. The goal is to identify w…

This study looks at whether using a smartphone app to monitor chronic wounds at home can reduce the number of in-person doctor visits. About 100 adults with a single chronic wound (like a diabetic foot ulcer or pressure sore) will be split into two groups: one gets standard care,…

This study tests a new way to monitor babies during labor to predict if they are at risk of brain damage from lack of oxygen. Researchers will use a special device to measure the baby's heart rate patterns in 760 pregnant women. The goal is to see if this method can help doctors …

This study looks at whether teaching family doctors special training can help slow kidney function loss in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Researchers will compare kidney decline rates between patients w…

This study will test a new screening method for congenital hypothyroidism (a thyroid hormone deficiency) in premature babies born before 32 weeks. Instead of the usual single test, researchers will do two tests within the first 15 days of life to see if this catches more cases. A…