Freeze then ointment: new combo tackles precancerous skin spots

NCT ID NCT07273656

Not yet recruiting Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether freezing precancerous skin spots (cryotherapy) followed by a medicated ointment (tirbanibulin) works better than freezing alone for actinic keratosis on the scalp and forehead. About 59 adults with at least 8 spots will receive the combo treatment or a placebo ointment after freezing, repeated every 4 months. The main goal is to see if all spots clear up at 8 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirbanibulin ointment
What this could lead to: If successful, this combination treatment could offer a more effective way to clear actinic keratosis lesions on the scalp and forehead, reducing the need for repeated procedures.
What could go wrong: This is a small Phase 3 trial (59 participants) and results may not apply to everyone. The treatment involves multiple cycles and side effects from cryotherapy or the ointment are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

actinic keratosis keratosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACTINIC KERATOSES KERATOSIS

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