Researchers investigate Cortisol's role in rare fat disorder

This study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this disease. Researchers measured cortisol-related substances in urine and checked enzyme activity in fat tissue from 25 participants. The findings may help understand the disease better but do not test any treatment.