Scientists probe Cortisol's role in rare fat disease

This study looked at how the body handles the hormone cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if a specific enzyme that reactivates cortisol is more active in these patients, which might contribute to their severe metabolic issues. Researchers measured cortisol-related substances in urine and fat tissue from 25 participants. The study did not test any treatment, but aimed to better understand the disease.